Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16] (2024)

30/08/2024 9:18pm

Edgar (US Regulatory)

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 6-K

Report of Foreign Private Issuer

Pursuant to Rule13a-16 or 15d-16

Under the Securities Exchange Act of 1934

For the Month of August 2024

001-36203

(Commission File Number)

CAN-FITE BIOPHARMA LTD.

(Exact name of Registrant as specified in its charter)

26 Ben Gurion Street

Ramat Gan 5257346 Israel

(Address of principal executive offices)

Indicate by check mark whether the registrantfiles or will file annual reports under cover Form20-F or Form40-F.

Form20-F☒Form40-F☐

This Report on Form 6-K(includingexhibits attached hereto)is hereby incorporated by reference into the registrant’s Registration Statements onForm S-8 (File Nos.333-227753,333-271384and333-278525) and Form F-3 (FileNos.333-236064,333-274316,333-262055 and 333-276000), to be a part thereof from the date on whichthis report is submitted, to the extent not superseded by documents or reports subsequently filed or furnished.

On August 30, 2024, Can-FiteBioPharma Ltd. (the “Company”) entered into an At The Market Offering Agreement (the “Offering Agreement”) withH.C. Wainwright & Co., LLC, as sales agent (“Wainwright”), pursuant to which the Company may offer and sell, from timeto time through Wainwright American Depositary Shares, each representing three hundred ordinary shares of the Company, no par value (the“Ordinary Shares”), having an aggregate offering price of up to $9.0 million (the “ADSs”).

The offer and sale ofthe ADSs will be made pursuant to a shelf registration statement on Form F-3 and the related prospectus (File No. 333-274316) filed bythe Company with the Securities and Exchange Commission (the “SEC”) on September 1, 2023, and declared effective by the SECon September 12, 2023, as supplemented by a prospectus supplement dated August 30, 2024, filed with the SEC pursuant to Rule 424(b) underthe Securities Act of 1933, as amended (the “Securities Act”).

Pursuant to the OfferingAgreement, sales of ADSs may be made in transactions that are deemed to be “at-the-market” offerings as defined in Rule415under the Securities Act, including sales made directly on or through The Nasdaq Capital Market, or any other existing trading marketin the Unites States for the Company’s ADSs, sales made to or through a market maker other than on an exchange or otherwise, directlyto Wainwright as principal, in negotiated transactions at market prices prevailing at the time of sale or at prices related to such prevailingmarket prices and/or in any other method permitted by law. Wainwright will use commercially reasonable efforts consistent with its normaltrading and sales practices and applicable law and regulations to sell the ADSs pursuant to the Offering Agreement from time to time,based upon instructions from the Company, including any price or size limits or other customary parameters or conditions the Company mayimpose.

The offering of ADSspursuant to the Offering Agreement will terminate upon the earliest of (a) the termination of the Offering Agreement by Wainwright orthe Company, as permitted therein, and (b) the mutual agreement of the parties. The Company will pay Wainwright a fixed commission rateequal to 3.0% of the gross sales priceof the ADSs sold pursuant to the Offering Agreement and has agreed to provide Wainwright withcustomary indemnification and contribution rights.

The Company will alsoreimburse Wainwright for certain specified expenses in connection with entering into the Offering Agreement. The Offering Agreement containscustomary representations and warranties and conditions to the sale of the ADSs pursuant thereto.

The foregoing description of the Offering Agreement is not complete and is qualified in its entirety by reference to the full text ofsuch agreement, a copy of which is filed herewith as Exhibit 10.1 to this Report on Form 6-K and is incorporated herein by reference.A copy of the opinion of Doron, Tikotzky, Kantor, Gutman, Amit Gross & Co. relating to the offer and sale of the ADSs is attachedas Exhibit 5.1 hereto.

This Report on Form 6-Kshall not constitute an offer to sell, or the solicitation of an offer to buy, the ADSs discussed herein, nor shall there be any offer,solicitation, or sale of securities in any state in which such offer, solicitation or sale would be unlawful prior to registration orqualification under the securities laws of any such state.

Exhibit Index

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SIGNATURES

Pursuant to the requirementsof the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereuntoduly authorized.

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Exhibit 5.1

With respect to our opinionas to the Ordinary Shares underlying the ADSs, we have assumed that, at the time of issuance and sale and to the extent any such issuancewould exceed the maximum share capital of the Company currently authorized, the number of Ordinary Shares that the Company is authorizedto issue shall have been increased in accordance with the Articles such that a sufficient number of Ordinary Shares are authorized andavailable for issuance under the Articles.

Members of our firm are admittedto the Bar in the State of Israel, and we do not express any opinion as to the laws of any other jurisdiction. This opinion is limitedto the matters stated herein and no opinion is implied or may be inferred beyond the matters expressly stated.

We consent to the filing ofthis opinion as an exhibit to the Registration Statement (as an exhibit to a Report of Foreign Private Issuer on Form 6-K that is incorporatedby reference in the Registration Statement) and to the reference to our firm appearing under the caption “Legal Matters” inthe Prospectus. In giving this consent, we do not thereby admit that we are within the category of persons whose consent is required underSection 7 of the Securities Act, the rules and regulations of the Commission promulgated thereunder or Item 509 of the Commission’sRegulation S-K under the Securities Act.

This opinion letter is renderedas of the date hereof and we disclaim any obligation to advise you of facts, circ*mstances, events or developments that may be broughtto our attention after the date of the Prospectus that may alter, affect or modify the opinions expressed herein.

Sincerely,

/s/ Doron, Tikotzky,Kantor, Gutman, Amit Gross & Co.,

Advocates & Notaries

Exhibit 10.1

AT THE MARKET OFFERING AGREEMENT

August 30,2024

H.C. Wainwright & Co., LLC

430 Park Avenue

New York, New York 10022

Ladies andGentlemen:

Can-Fite Biopharma Ltd., acorporation organized under the laws of the State of Israel (the “Company”), confirms its agreement (this “Agreement”)with H.C. Wainwright & Co., LLC (the “Manager”) as follows:

1. Definitions.The terms that follow, when used in this Agreement and any Terms Agreement, shall have the meanings indicated.

“Accountants”shallhave the meaning ascribed to such term in Section 4(m).

“Act”shall mean the Securities Act of 1933, as amended, and the rules and regulations of the Commission promulgated thereunder.

“Action”shall have the meaning ascribed to such term in Section 3(p).

“ADS(s)”means American Depositary Shares issued pursuant to the Deposit Agreement (as defined below), each representing three hundred (300) OrdinaryShares.

“Affiliate”shall have the meaning ascribed to such term in Section 3(o).

“ApplicableTime” shall mean, with respect to any ADSs, the time of sale of such ADSs pursuant to this Agreement or any relevant Terms Agreement.

“Base Prospectus”shall mean the base prospectus contained in the Registration Statement at the Execution Time.

“Board”shall have the meaning ascribed to such term in Section 2(b)(iii).

“BrokerFee” shall have the meaning ascribed to such term in Section 2(b)(v).

“BusinessDay” shall mean any day other than Saturday, Sunday or other day on which commercial banks in The City of New York or the Stateof Israel are authorized or required by law to remain closed; provided, however, that, for purposes of clarity, commercialbanks shall not be deemed to be authorized or required by law to remain closed due to “stay at home”, “shelter-in-place”,“non-essential employee” or any other similar orders or restrictions or the closure of any physical branch locationsat the direction of any governmental authority so long as the electronic funds transfer systems (including for wire transfers) of commercialbanks in The City of New York generally are open for use by customers on such day.

“Commission”shall mean the United States Securities and Exchange Commission.

“CompanyIsraeli Counsel” means Doron, Tikotzky, Kantor, Gutman, Amit Gross and Co., with offices located at B.S.R. 4 Tower, 33rd Floor,7 Metsada Street, Bnei Brak 5126112 Israel.

“CompanyU.S. Counsel” means Greenberg Traurig, P.A., with offices located at One Azrieli Center, Round Tower, 30th floor, 132 MenachemBegin Rd, Tel Aviv 6701101.

“DepositAgreement” means the Deposit Agreement, dated as of September 19, 2012, as amended and restated as of September 11, 2013, amongthe Company, The Bank of New York Mellon, as Depositary, and the owners and holders of ADSs from time to time, as such agreement may beamended or supplemented.

“Depositary”means The Bank of New York Mellon, as Depositary under the Deposit Agreement, and any successor as depositary under the Deposit Agreement.

“Depositary’sCounsel” shall mean Emmet, Marvin & Martin, LLP, with offices located at 120 Broadway, New York, New York 10271.

“DTC”shall have the meaning ascribed to such term in Section 2(b)(vii).

“EffectiveDate” shall mean each date and time that the Registration Statement and any post-effective amendment or amendments thereto becameor becomes effective.

“ExchangeAct” shall mean the Securities Exchange Act of 1934, as amended, and the rules and regulations of the Commission promulgatedthereunder.

“ExecutionTime” shall mean the date and time that this Agreement is executed and delivered by the parties hereto.

“Free WritingProspectus” shall mean a free writing prospectus, as defined in Rule405.

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“GAAP”shall have the meaning ascribed to such term in Section 3(m).

“IncorporatedDocuments” shall mean the documents or portions thereof filed with the Commission on or prior to the Effective Date that areincorporated by reference in the Registration Statement or the Prospectus and any documents or portions thereof filed with the Commissionafter the Effective Date that are deemed to be incorporated by reference in the Registration Statement or the Prospectus.

“IntellectualProperty Rights” shall have the meaning ascribed to such term in Section 3(v).

“IssuerFree Writing Prospectus” shall mean an issuer free writing prospectus, as defined in Rule433.

“Losses”shall have the meaning ascribed to such term in Section 7(d).

“MaterialAdverse Effect” shall have the meaning ascribed to such term in Section 3(b).

“MaterialPermits” shall have the meaning ascribed to such term in Section 3(t).

“Net Proceeds”shall have the meaning ascribed to such term in Section 2(b)(v).

“OrdinaryShares” means the ordinary shares of the Company, no par value, and any other class of securities into which such securitiesmay hereafter be reclassified or changed.

“OrdinaryShare Equivalents” means any securities of the Company or the Subsidiaries which would entitle the holder thereof to acquireat any time Ordinary Shares or ADSs, including, without limitation, any debt, preferred shares, right, option, warrant or other instrumentthat is at any time convertible into or exercisable or exchangeable for, or otherwise entitles the holder thereof to receive, OrdinaryShares or ADSs.

“PermittedFree Writing Prospectus” shall have the meaning ascribed to such term in Section 4(g).

“Placement”shall have the meaning ascribed to such term in Section 2(c).

“Proceeding”shall have the meaning ascribed to such term in Section 3(b).

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“Prospectus”shall mean the Base Prospectus, as supplemented by the most recently filed Prospectus Supplement (if any).

“ProspectusSupplement” shall mean each prospectus supplement relating to the Ordinary Shares represented by ADSs prepared and filed pursuantto Rule424(b) from time to time.

“RegistrationStatement” shall mean the shelf registration statement (File Number333-274316) on FormF-3, including exhibits andfinancial statements filed with or incorporated by reference into such registration statement and any prospectus supplement relating tothe Ordinary Shares represented by ADSs that is filed with the Commission pursuant to Rule424(b) and deemed part of such registrationstatement pursuant to Rule430B, as amended on each Effective Date and, in the event any post-effective amendment thereto becomeseffective, shall also mean such registration statement as so amended.

“RepresentationDate” shall have the meaning ascribed to such term in Section 4(k).

“RequiredApprovals” shall have the meaning ascribed to such term in Section 3(e).

“Rule158”,“Rule164”, “Rule172”, “Rule173”, “Rule405”,“Rule415”, “Rule424”, “Rule430B” and “Rule433”refer to such rules under the Act.

“SalesNotice” shall have the meaning ascribed to such term in Section 2(b)(i).

“SEC Reports”shall have the meaning ascribed to such term in Section 3(m).

“SettlementDate” shall have the meaning ascribed to such term in Section 2(b)(vii).

“Subsidiary”shall have the meaning ascribed to such term in Section 3(a).

“TermsAgreement” shall have the meaning ascribed to such term in Section 2(a).

“Time ofDelivery” shall have the meaning ascribed to such term in Section 2(c).

“TradingDay” means a day on which the Trading Market is open for trading.

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“TradingMarket” means whichever of the New York Stock Exchange, the NYSE American, the Nasdaq Global Select Market, the Nasdaq GlobalMarket or the Nasdaq Capital Market on which the ADSs are listed or quoted for trading on the date in question.

2. Saleand Delivery of ADSs. The Company proposes to issue and sell through or to the Manager, as sales agent and/or principal, from timeto time during the term of this Agreement and on the terms set forth herein, up to such number of Ordinary Shares represented by ADSsthat does not exceed (a) the number or dollar amount of ADSs representing the amount of Ordinary Shares registered on the Prospectus Supplement,pursuant to which the offering is being made, (b) the maximum number of Ordinary Shares represented by ADSs authorized for issuance hereunderand representing the maximum number of authorized but unissued Ordinary Shares (less the number of Ordinary Shares issuable upon exercise,conversion or exchange of any outstanding securities of the Company or otherwise reserved from the Company’s authorized OrdinaryShares), or (c) the number or dollar amount of ADSs representing the maximum number of Ordinary Shares that would cause the Company orthe offering of the ADSs to not satisfy the eligibility and transaction requirements for use of Form F-3, including, if applicable, GeneralInstruction I.B.5 of Registration Statement on Form F-3 (the lesser of (a), (b) and (c), the “Maximum Amount”). Notwithstandinganything to the contrary contained herein, the parties hereto agree that compliance with the limitations set forth in this Section 2 onthe number and aggregate sales price of ADSs issued and sold under this Agreement shall be the sole responsibility of the Company andthat the Manager shall have no obligation in connection with such compliance.

(a) Appointmentof Manager as Selling Agent; Terms Agreement. For purposes of selling the ADSs through the Manager, the Company hereby appoints theManager as exclusive agent of the Company for the purpose of selling the ADSs pursuant to this Agreement and the Manager agrees to useits commercially reasonable efforts to sell the ADSs on the terms and subject to the conditions stated herein. The Company agrees that,whenever it determines to sell the ADSs directly to the Manager as principal, it will enter into a separate agreement (each, a “TermsAgreement”) in substantially the form of Annex I hereto, relating to such sale in accordance with Section2 of thisAgreement.

(b) AgentSales. Subject to the terms and conditions and in reliance upon the representations and warranties herein set forth, the Company willissue and agrees to sell ADSs from time to time through the Manager, acting as sales agent, and the Manager agrees to use its commerciallyreasonable efforts to sell, as sales agent for the Company, on the following terms:

(i) TheADSs are to be sold on a daily basis or otherwise as shall be agreed to by the Company and the Manager on any day that (A)is a TradingDay, (B)the Company has instructed the Manager by telephone (confirmed promptly by electronic mail) to make such sales (“SalesNotice”) and (C) the Company has satisfied its obligations under Section 6 of this Agreement. The Company will designate themaximum amount of the ADSs to be sold by the Manager daily (subject to the limitations set forth in Section 2(d)) and the minimum priceper ADS at which such ADSs may be sold. Subject to the terms and conditions hereof, the Manager shall use its commercially reasonableefforts to sell on a particular day all of the ADSs designated for the sale by the Company on such day. The gross sales price of the ADSssold under this Section2(b) shall be the market price for the ADSs sold by the Manager under this Section2(b) on the TradingMarket at the time of sale of such ADSs.

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(ii) TheCompany acknowledges and agrees that (A)there can be no assurance that the Manager will be successful in selling the ADSs, (B)theManager will incur no liability or obligation to the Company or any other Person if it does not sell the ADSs for any reason other thana failure by the Manager to use its commercially reasonable efforts consistent with its normal trading and sales practices and applicablelaw and regulations to sell such ADSs as required under this Agreement, and (C)the Manager shall be under no obligation to purchaseADSs on a principal basis pursuant to this Agreement, except as otherwise specifically agreed by the Manager and the Company pursuantto a Terms Agreement.

(iii) TheCompany shall not authorize the issuance and sale of, and the Manager shall not be obligated to use its commercially reasonable effortsto sell, any ADS at a price lower than the minimum price therefor designated from time to time by the Company’s Board of Directors(the “Board”), or a duly authorized committee thereof, or such duly authorized officers of the Company, and notifiedto the Manager in writing. The Company or the Manager may, upon notice to the other party hereto by telephone (confirmed promptly by electronicmail), suspend the offering of the ADSs for any reason and at any time; provided, however, that such suspension or terminationshall not affect or impair the parties’ respective obligations with respect to the ADSs sold hereunder prior to the giving of suchnotice.

(iv) TheManager may sell ADSs by any method permitted by law deemed to be an “at the market offering” as defined in Rule415under the Act, including without limitation sales made directly on the Trading Market, on any other existing trading market for the ADSsor to or through a market maker. The Manager may also sell ADSs in privately negotiated transactions, provided that the Manager receivesthe Company’s prior written approval for any sales in privately negotiated transactions and if so provided in the “Plan ofDistribution” section of the Prospectus Supplement or a supplement to the Prospectus Supplement or a new Prospectus Supplement disclosingthe terms of such privately negotiated transaction.

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(v) Thecompensation to the Manager for sales of the ADSs under this Section 2(b) shall be a placement fee of 3.0% of the gross sales price ofthe ADSs sold pursuant to this Section 2(b) (“Broker Fee”). The foregoing rate of compensation shall not apply whenthe Manager acts as principal, in which case the Company may sell ADSs to the Manager as principal at a price agreed upon at the relevantApplicable Time pursuant to a Terms Agreement. The remaining proceeds, after deduction of the Broker Fee and deduction of any transactionfees imposed by any clearing firm, execution broker, or governmental or self-regulatory organization in respect of such sales, shall constitutethe net proceeds to the Company for such ADSs (the “Net Proceeds”).

(vi) TheManager shall provide written confirmation (which may be by facsimile or electronic mail) to the Company following the close of tradingon the Trading Market each day in which the ADSs are sold under this Section 2(b) setting forth the number of the ADSs sold on such day,the aggregate gross sales proceeds and the Net Proceeds to the Company, and the compensation payable by the Company to the Manager withrespect to such sales.

(vii) Unlessotherwise agreed between the Company and the Manager, settlement for sales of the ADSs will occur at 10:00 a.m. (New York City time) onthe first (1st) Trading Day (or any such shorter settlement cycle as may be ineffect pursuant to Rule 15c6-1 under the Exchange Act from time to time) following the date on which such sales are made (each,a “Settlement Date”). On or before the Trading Day prior to each Settlement Date, the Company will, or will cause (tothe extent possible) its transfer agent to, issue and deposit with the Depositary’s custodian the number of Ordinary Shares to representedby the ADSs being sold and instruct the Depositary to deliver that number of ADSs by crediting the Manager’s or its designee’saccount (provided that the Manager shall have given the Company written notice of such designee at least one Trading Day prior to theSettlement Date) at The Depository Trust Company (“DTC”) through its Deposit and Withdrawal at Custodian System orby such other means of delivery as may be mutually agreed upon by the parties hereto which ADSs in all cases shall be freely tradable,transferable, registered ADSs in good deliverable form. On each Settlement Date, the Manager will deliver the related Net Proceeds insame day funds to an account designated by the Company. The Company agrees that, if the Company, or its transfer agent (if applicable),defaults in its obligation to deliver duly authorized ADSs on a Settlement Date, in addition to and in no way limiting the rights andobligations set forth in Section 7 hereto, the Company will (i) hold the Manager harmless against any loss, claim, damage, or reasonable,documented expense (including reasonable and documented legal fees and expenses), as incurred, arising out of or in connection with suchdefault by the Company, and (ii) pay to the Manager any commission, discount or other compensation to which the Manager would otherwisehave been entitled absent such default.

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(viii) Ateach Applicable Time, Settlement Date, and Representation Date, the Company shall be deemed to have affirmed each representation and warrantycontained in this Agreement as if such representation and warranty were made as of such date, modified as necessary to relate to the RegistrationStatement and the Prospectus as amended as of such date (except for any representation and warranty which is as of a specific date, inwhich case such representation and warranty shall be affirmed as of such specific date). Any obligation of the Manager to use its commerciallyreasonable efforts to sell the ADSs on behalf of the Company shall be subject to the continuing accuracy of the representations and warrantiesof the Company herein, to the performance by the Company of its obligations hereunder and to the continuing satisfaction of the additionalconditions specified in Section 6 of this Agreement.

(ix) Ifthe Company shall declare or make any dividend or other distribution of its assets (or rights to acquire its assets) to holders of itssecurities (including Ordinary Shares or ADSs), by way of return of capital or otherwise (including, without limitation, any distributionof cash, shares or other securities, property or options by way of a dividend, spin off, reclassification, corporate rearrangement, schemeof arrangement or other similar transaction) (a “Distribution” and the record date for the determination of shareholdersentitled to receive the Distribution, the “Record Date”), the Company hereby covenants that, in connection with anysales of ADSs pursuant to a Sales Notice on the Record Date, the Company shall issue and deliver such ADSs to the Manager on the RecordDate and the Record Date shall be the Settlement Date and the Company shall cover any additional costs of the Manager in connection withthe delivery of ADSs on the Record Date.

(c) TermSales. If the Company wishes to sell the ADSs pursuant to this Agreement in a manner other than as set forth in Section 2(b) of thisAgreement (each, a “Placement”), the Company will notify the Manager of the proposed terms of such Placement. If theManager, acting as principal, wishes to accept such proposed terms (which it may decline to do for any reason in its sole discretion)or, following discussions with the Company wishes to accept amended terms, the Manager and the Company will enter into a Terms Agreementsetting forth the terms of such Placement. The terms set forth in a Terms Agreement will not be binding on the Company or the Managerunless and until the Company and the Manager have each executed such Terms Agreement accepting all of the terms of such Terms Agreement.In the event of a conflict between the terms of this Agreement and the terms of a Terms Agreement, the terms of such Terms Agreement willcontrol. A Terms Agreement may also specify certain provisions relating to the reoffering of such ADSs by the Manager. The commitmentof the Manager to purchase the ADSs pursuant to any Terms Agreement shall be deemed to have been made on the basis of the representationsand warranties of the Company herein contained and shall be subject to the terms and conditions herein set forth. Each Terms Agreementshall specify the number of the ADSs to be purchased by the Manager pursuant thereto, the price to be paid to the Company for such ADSs,any provisions relating to rights of, and default by, underwriters acting together with the Manager in the reoffering of the ADSs, andthe time and date (each such time and date being referred to herein as a “Time of Delivery”) and place of deliveryof and payment for such ADSs. Such Terms Agreement shall also specify any requirements for opinions of counsel, accountants’ lettersand officers’ certificates pursuant to Section 6 of this Agreement and any other information or documents required by the Manager.

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(d) MaximumNumber of ADSs. Under no circ*mstances shall the Company cause or request the offer or sale of any ADSs if, after giving effect tothe sale of such ADSs, the aggregate amount of ADSs sold pursuant to this Agreement would exceed the lesser of (A) together with all salesof ADSs under this Agreement, the Maximum Amount, (B) the amount available for offer and sale under the currently effective RegistrationStatement and (C) the amount authorized from time to time to be issued and sold under this Agreement by the Board, a duly authorized committeethereof or a duly authorized executive committee, and notified to the Manager in writing. Under no circ*mstances shall the Company causeor request the offer or sale of any ADSs pursuant to this Agreement at a price lower than the minimum price authorized from time to timeby the Board, a duly authorized committee thereof or a duly authorized executive officer, and notified to the Manager in writing. Further,under no circ*mstances shall the Company cause or permit the aggregate offering amount of Ordinary Shares represented by ADSs sold pursuantto this Agreement to exceed the Maximum Amount.

(e) RegulationM Notice. Unless the exceptive provisions set forth in Rule101(c)(1) of RegulationM under the Exchange Act are satisfiedwith respect to the ADSs, the Company shall give the Manager at least one (1) Trading Day’s prior notice of its intent to sell anyADSs in order to allow the Manager time to comply with Regulation M.

3. Representationsand Warranties. The Company represents and warrants to, and agrees with, the Manager at the Execution Time and on each such time thatthe following representations and warranties are repeated or deemed to be made pursuant to this Agreement (except to the extent such representationand warranty specifies a different time), as set forth below, except as set forth in the Registration Statement, the Prospectus or theIncorporated Documents.

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(a) Subsidiaries.All of the direct and indirect subsidiaries (individually, a “Subsidiary”) of the Company are set forth on Exhibit21.1 to the Company’s most recent Annual Report on Form 20-F filed with the Commission. The Company owns, directly or indirectly,all of the share capital or other equity interests of each Subsidiary free and clear of any “Liens” (which for purposesof this Agreement shall mean a lien, charge, security interest, encumbrance, right of first refusal, preemptive right or other restriction),and all of the issued and outstanding share capital and other equity interests of each Subsidiary are validly issued and are fully paid,non-assessable and free of preemptive and similar rights to subscribe for or purchase securities.

(b) Organizationand Qualification. The Company and each of the Subsidiaries is an entity duly incorporated or otherwise organized, validly existingand, if applicable under the laws of the jurisdiction in which it was formed, in good standing under the laws of the jurisdiction of itsincorporation or organization, with the requisite power and authority to own and use its properties and assets and to carry on its businessas currently conducted, except where the failure of a Subsidiary to be in good standing would not have a Material Adverse Effect. Neitherthe Company nor any Subsidiary is in violation nor in default of any of the provisions of its respective certificate or articles of incorporationor memorandum and articles of association, as applicable, bylaws (if applicable) or other organizational or charter documents. Each ofthe Company and the Subsidiaries is duly qualified to conduct business and is in good standing as a foreign corporation or other entityin each jurisdiction in which the nature of the business conducted or property owned by it makes such qualification necessary, exceptwhere the failure to be so qualified or in good standing, as the case may be, could not have or reasonably be expected to result in: (i)a material adverse effect on the legality, validity or enforceability of this Agreement, (ii) a material adverse effect on the resultsof operations, assets, business, prospects or condition (financial or otherwise) of the Company and the Subsidiaries, taken as a whole,from that set forth in the Registration Statement, the Base Prospectus, any Prospectus Supplement, the Prospectus or the IncorporatedDocuments, or (iii) a material adverse effect on the Company’s ability to perform in any material respect on a timely basis itsobligations under this Agreement (any of (i), (ii) or (iii), a “Material Adverse Effect”) and no “Proceeding”(which for purposes of this Agreement shall mean any action, claim, suit, investigation or proceeding (including, without limitation,an informal investigation or partial proceeding, such as a deposition), whether commenced or threatened) has been instituted in any suchjurisdiction revoking, limiting or curtailing or seeking to revoke, limit or curtail such power and authority or qualification. Neitherthe Company nor any of its Israeli subsidiaries is currently designated as a "breaching company" (within the meaning of theIsraeli Companies Law, 1999) (the "Companies Law") by the Registrar of Companies of the State of Israel, nor has a proceedingbeen instituted in Israel by the Registrar of Companies of the State of Israel for the dissolution of the Company or any of its Israelisubsidiaries.

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(c) Authorizationand Enforcement. The Company has the requisite corporate power and authority to enter into and to consummate the transactions contemplatedby this Agreement and otherwise to carry out its obligations hereunder. The execution and delivery of this Agreement by the Company andthe consummation by it of the transactions contemplated hereby have been duly authorized by all necessary action on the part of the Companyand no further action is required by the Company, the Board or the Company’s shareholders in connection herewith other than in connectionwith the Required Approvals. This Agreement has been duly executed and delivered by the Company and, when delivered in accordance withthe terms hereof, will constitute the valid and binding obligation of the Company enforceable against the Company in accordance with itsterms, except (i) as limited by general equitable principles and applicable bankruptcy, insolvency, reorganization, moratorium and otherlaws of general application affecting enforcement of creditors’ rights generally, (ii) as limited by laws relating to the availabilityof specific performance, injunctive relief or other equitable remedies and (iii) insofar as indemnification and contribution provisionsmay be limited by applicable law.

(d) NoConflicts. The execution, delivery and performance by the Company of this Agreement, the issuance of the Ordinary Shares and saleof the ADSs representing such Ordinary Shares and the consummation by it of the transactions contemplated hereby do not and will not (i)conflict with or violate any provision of the Company’s or any Subsidiary’s certificate or articles of incorporation or memorandumand articles of association, bylaws or other organizational or charter documents, or (ii) conflict with, or constitute a default (or anevent that with notice or lapse of time or both would become a default) under, result in the creation of any Lien upon any of the propertiesor assets of the Company or any Subsidiary, or give to others any rights of termination, amendment, anti-dilution or similar adjustments,acceleration or cancellation (with or without notice, lapse of time or both) of, any agreement, credit facility, debt or other instrument(evidencing a Company or Subsidiary debt or otherwise) or other understanding to which the Company or any Subsidiary is a party or bywhich any property or asset of the Company or any Subsidiary is bound or affected, or (iii) subject to the Required Approvals, conflictwith or result in a violation of any law, rule, regulation, order, judgment, injunction, decree or other restriction of any court or governmentalauthority to which the Company or a Subsidiary is subject (including federal and state securities laws and regulations), or by which anyproperty or asset of the Company or a Subsidiary is bound or affected; except in the case of each of clauses (ii) and (iii), such as couldnot, individually or in the aggregate, have or reasonably be expected to result in a Material Adverse Effect.

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(e) Filings,Consents and Approvals. The Company is not required to obtain any consent, waiver, authorization or order of, give any notice to,or make any filing or registration with, any court or other federal, state, local, Israeli or other non-US governmental authority or other“Person” (defined as an individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture,limited liability company, joint stock company, government (or an agency or subdivision thereof) or other entity of any kind, includingthe Trading Market) in connection with the execution, delivery and performance by the Company of this Agreement, other than (i) the filingsrequired by this Agreement, (ii) the filing with the Commission of the Prospectus Supplement, (iii) the filing of application(s) to andapproval by the Trading Market for the listing of the ADSs for trading thereon in the time and manner required thereby, and (iv) suchfilings as are required to be made under applicable U.S. state or non-U.S. securities laws and the rules and regulations of the FinancialIndustry Regulatory Authority, Inc. (“FINRA”) or the laws of Israel (collectively, the “Required Approvals”).

(f) Issuanceof Ordinary Shares and ADSs. The Ordinary Shares represented by the ADSs are duly authorized and, when issued and paid for in accordancewith this Agreement, will be duly and validly issued, fully paid and nonassessable, free and clear of all Liens imposed by the Company.The Company has reserved from its duly authorized shares capital a sufficient number of Ordinary Shares for the issuance of the ADSs issuablepursuant to this Agreement. The offer and sale by the Company of the Ordinary Shares represented by ADSs and the offer and sale of theADSs has been registered under the Act and all of the ADSs are freely transferable and tradable by the purchasers thereof without restriction(other than any restrictions arising solely from an act or omission of such a purchaser). The Ordinary Shares represented by ADSs arebeing offered and sold pursuant to the Registration Statement and the issuance of the Ordinary Shares has been registered by the Companyunder the Act. The Company and the Depositary have prepared and filed with the Commission registration statements relating to the ADSson Form F-6 (File No. 333-183741 and 333-249933) for the registration of the ADSs under the Act, which became effective on September 19,2012 and November 6, 2020, respectively, and are effective as of the date hereof. The “Plan of Distribution” sectionwithin the Registration Statement permits the offer and sale of the Ordinary Shares represented by ADSs as contemplated by this Agreement.Upon receipt of the ADSs, the purchasers of such ADSs will have good and marketable title to such ADSs and the ADSs will be freely tradableon the Trading Market.

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(g) Capitalization.The capitalization of the Company is as set forth in the SEC Reports. The Company has not issued any share capital, Ordinary Shares, includingOrdinary Shares represented by ADSs, since its most recently filed periodic report under the Exchange Act, other than pursuant to theexercise of employee share options under the Company’s share option plans, the issuance of Ordinary Shares or ADSs to employeespursuant to the Company’s employee share purchase plan and pursuant to the conversion and/or exercise of securities exercisable,exchangeable or convertible into Ordinary Shares, including Ordinary Shares represented by ADSs, (“Ordinary Share Equivalents”)outstanding as of the date of the most recently filed periodic report under the Exchange Act. No Person has any right of first refusal,preemptive right, right of participation, or any similar right to participate in the transactions contemplated by this Agreement. Exceptas set forth in the SEC Reports, there are no outstanding options, warrants, scrip rights to subscribe to, calls or commitments of anycharacter whatsoever relating to, or securities, rights or obligations convertible into or exercisable or exchangeable for, or givingany Person any right to subscribe for or acquire, any Ordinary Shares, including Ordinary Shares represented by ADSs, or the share capitalof any Subsidiary, or contracts, commitments, understandings or arrangements by which the Company or any Subsidiary is or may become boundto issue additional Ordinary Shares, including Ordinary Shares represented by ADSs, or Ordinary Share Equivalents or share capital ofany Subsidiary. The issuance and sale of the Ordinary Shares represented by the ADSs pursuant to this Agreement will not obligate theCompany or any Subsidiary to issue Ordinary Shares, including Ordinary Shares represented by ADSs, or other securities to any Person.Except as set forth in the SEC Reports, there are no outstanding securities or instruments of the Company or any Subsidiary with any provisionthat adjusts the exercise, conversion, exchange or reset price of such security or instrument upon an issuance of securities by the Companyor any Subsidiary. Except as set forth in the SEC Reports, there are no outstanding securities or instruments of the Company or any Subsidiarythat contain any redemption or similar provisions, and there are no contracts, commitments, understandings or arrangements by which theCompany or any Subsidiary is or may become bound to redeem a security of the Company or such Subsidiary. The Company does not have anyshare appreciation rights or “phantom stock” plans or agreements or any similar plan or agreement. All of the outstandingOrdinary Shares of the Company, including Ordinary Shares represented by ADSs, are duly authorized, validly issued, fully paid and nonassessable,have been issued in compliance with all federal and state securities laws, and none of such outstanding shares was issued in violationof any preemptive rights or similar rights to subscribe for or purchase securities. No further approval or authorization of any shareholder,the Board or others is required for the issuance and sale of the Ordinary Shares represented by the ADSs pursuant to this Agreement. Exceptas set forth in the SEC Reports, there are no shareholders agreements, voting agreements or other similar agreements with respect to theCompany’s Ordinary Shares, Ordinary Shares represented by ADSs or share capital to which the Company is a party or, to the knowledgeof the Company, between or among any of the Company’s shareholders.

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(h) RegistrationStatement. The Company meets the requirements for use of FormF-3 under the Act and has prepared and filed with the Commissionthe Registration Statement, including a related Base Prospectus, for registration under the Act of the offering and sale of the OrdinaryShares represented by the ADSs. The Registration Statement is effective and available for the offer and sale of the Ordinary Shares representedby ADSs as of the date hereof. As filed, the Base Prospectus contains in all material respects all information required by the Act andthe rules thereunder, and, except to the extent the Manager shall agree in writing to a modification, shall be in all substantive respectsin the form furnished to the Manager prior to the Execution Time or prior to any such time this representation is repeated or deemed tobe made. The Registration Statement, at the Execution Time, each such time this representation is repeated or deemed to be made, and atall times during which a prospectus is required by the Act to be delivered (whether physically or through compliance with Rule172,173 or any similar rule) in connection with any offer or sale of the Ordinary Shares represented by ADSs, meets the requirements set forthin Rule415(a)(1)(x). The initial Effective Date of the Registration Statement was not earlier than the date three years before theExecution Time. The Company meets the transaction requirements as set forth in General Instruction I.B.1 of Form F-3 or, if applicable,as set forth in General Instruction I.B.5 of Form F-3 with respect to the aggregate market value of securities being sold pursuant tothis offering and during the twelve (12) months prior to this offering.

(i) Accuracyof Incorporated Documents. The Incorporated Documents, when they were filed with the Commission, conformed in all material respectsto the requirements of the Exchange Act and the rules thereunder, and none of the Incorporated Documents, when they were filed with theCommission, contained any untrue statement of a material fact or omitted to state a material fact necessary to make the statements therein,in light of the circ*mstances under which they were made not misleading; and any further documents so filed and incorporated by referencein the Registration Statement, the Base Prospectus, the Prospectus Supplement or the Prospectus, when such documents are filed with theCommission, will conform in all material respects to the requirements of the Exchange Act and the rules thereunder, as applicable, andwill not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements therein, inlight of the circ*mstances under which they were made, not misleading.

(j) IneligibleIssuer. (i)At the earliest time after the filing of the Registration Statement that the Company or another offering participantmade a bona fide offer (within the meaning of Rule164(h)(2)) of the ADSs and (ii)as of the Execution Time and on each suchtime this representation is repeated or deemed to be made (with such date being used as the determination date for purposes of this clause(ii)),the Company was not and is not an Ineligible Issuer (as defined in Rule405), without taking account of any determination by theCommission pursuant to Rule405 that it is not necessary that the Company be considered an Ineligible Issuer.

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(k) FreeWriting Prospectus. The Company is eligible to use Issuer Free Writing Prospectuses. Each Issuer Free Writing Prospectus does notinclude any information the substance of which conflicts with the information contained in the Registration Statement, including any IncorporatedDocuments and any prospectus supplement deemed to be a part thereof that has not been superseded or modified; and each Issuer Free WritingProspectus does not contain any untrue statement of a material fact or omit to state any material fact necessary in order to make thestatements therein, in the light of the circ*mstances under which they were made, not misleading. The foregoing sentence does not applyto statements in or omissions from any Issuer Free Writing Prospectus based upon and in conformity with written information furnishedto the Company by the Manager specifically for use therein. Any Issuer Free Writing Prospectus that the Company is required to file pursuantto Rule 433(d) has been, or will be, filed with the Commission in accordance with the requirements of the Act and the rules thereunder.Each Issuer Free Writing Prospectus that the Company has filed, or is required to file, pursuant to Rule 433(d) or that was prepared byor behalf of or used by the Company complies or will comply in all material respects with the requirements of the Act and the rules thereunder.The Company will not, without the prior consent of the Manager, prepare, use or refer to, any Issuer Free Writing Prospectuses.

(l) ProceedingsRelated to Registration Statement. The Registration Statement is not the subject of a pending proceeding or examination under Section8(d)or 8(e) of the Act, and the Company is not the subject of a pending proceeding under Section8A of the Act in connection with theoffering of the ADSs. The Company has not received any notice that the Commission has issued or intends to issue a stop-order with respectto the Registration Statement or that the Commission otherwise has suspended or withdrawn the effectiveness of the Registration Statement,either temporarily or permanently, or intends or has threatened in writing to do so.

(m) SECReports. The Company has complied in all material respects with requirements to file all reports, schedules, forms, statements andother documents required to be filed by the Company under the Act and the Exchange Act, including pursuant to Section 13(a) or 15(d) thereof,for the one year preceding the date hereof (or such shorter period as the Company was required by law or regulation to file such material)(the foregoing materials, including the exhibits thereto and documents incorporated by reference therein, together with the Prospectusand the Prospectus Supplement, being collectively referred to herein as the “SEC Reports”) on a timely basis or hasreceived a valid extension of such time of filing and has filed any such SEC Reports prior to the expiration of any such extension. Asof their respective dates, the SEC Reports complied in all material respects with the requirements of the Act and the Exchange Act, asapplicable, and none of the SEC Reports, when filed, contained any untrue statement of a material fact or omitted to state a materialfact required to be stated therein or necessary in order to make the statements therein, in the light of the circ*mstances under whichthey were made, not misleading. The financial statements of the Company included in the SEC Reports comply in all material respects withapplicable accounting requirements and the rules and regulations of the Commission with respect thereto as in effect at the time of filing.The interactive data in eXtensible Business Reporting Language included or incorporated by reference in the Registration Statement fairlypresents the information called for in all material respects and has been prepared in accordance with the Commission's rules and guidelinesapplicable thereto. No other financial statements or supporting schedules are required to be included in the Registration Statement, theBase Prospectus, any Prospectus Supplement or the Prospectus. Such financial statements have been prepared in accordance with United Statesgenerally accepted accounting principles applied on a consistent basis during the periods involved (“GAAP”), exceptas may be otherwise specified in such financial statements or the notes thereto and except that unaudited financial statements may notcontain all footnotes required by GAAP, and fairly present in all material respects the financial position of the Company and its consolidatedSubsidiaries as of and for the dates thereof and the results of operations and cash flows for the periods then ended, subject, in thecase of unaudited statements, to normal, immaterial, year-end audit adjustments.

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(n)Statistical and Market-Related Data. All statistical, demographic and market-related data included in the Registration Statementor the Prospectus are based on or derived from sources that the Company believes, after reasonable inquiry, to be reliable and accurate.To the extent required, the Company has obtained the written consent for the use of such data from such sources.

(o) MaterialChanges; Undisclosed Events, Liabilities or Developments. Since the date of the latest audited financial statements included withinthe SEC Reports, except as specifically disclosed in a subsequent SEC Report filed prior to the date on which this representation is beingmade, (i) there has been no event, occurrence or development that has had or that could reasonably be expected to result in a MaterialAdverse Effect, (ii) the Company has not incurred any liabilities (contingent or otherwise) other than (A) trade payables and accruedexpenses incurred in the ordinary course of business consistent with past practice and (B) liabilities not required to be reflected inthe Company’s financial statements pursuant to GAAP or disclosed in filings made with the Commission, (iii) the Company has notaltered its method of accounting, (iv) the Company has not declared or made any dividend or distribution of cash or other property toits shareholders or purchased, redeemed or made any agreements to purchase or redeem any of its capital shares, (v) the Company has notissued any equity securities to any officer, director or “Affiliate” (defined as any Person that, directly or indirectlythrough one or more intermediaries, controls or is controlled by or is under common control with a Person, as such terms are used in andconstrued under Rule 144 under the Act), except pursuant to existing Company share option plans, and (vi) no executive officer of theCompany or member of the Board has resigned from any position with the Company. The Company does not have pending before the Commissionany request for confidential treatment of information. Except for the issuance of the ADSs contemplated by this Agreement, no event, liability,fact, circ*mstance, occurrence or development has occurred or exists or is reasonably expected to occur or exist with respect to the Companyor its Subsidiaries or their respective businesses, prospects, properties, operations, assets or financial condition that would be requiredto be disclosed by the Company under applicable securities laws at the time this representation is made or deemed made that has not beenpublicly disclosed at least one (1) Trading Day prior to the time that this representation is made.

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(p) Litigation.Except as set forth in the SEC Reports, there is no action, suit, inquiry, notice of violation, proceeding or investigation pending or,to the knowledge of the Company, threatened against or affecting the Company, any Subsidiary or any of their respective properties beforeor by any court, arbitrator, governmental or administrative agency or regulatory authority (federal, state, county, local, Israeli orother non-U.S.) (collectively, an “Action”). None of the Actions set forth in the SEC Reports, (i) adversely affectsor challenges the legality, validity or enforceability of this Agreement or the ADSs or (ii) could, if there were an unfavorable decision,have or reasonably be expected to result in a Material Adverse Effect. Neither the Company nor any Subsidiary, nor, to the knowledge ofthe Company, any director or officer thereof, is or has been the subject of any Action involving a claim of violation of or liabilityunder federal or state securities laws or a claim of breach of fiduciary duty. There has not been, and to the knowledge of the Company,there is not pending or contemplated, any investigation by the Commission involving the Company or, to the knowledge of the Company, anycurrent or former director or officer of the Company. The Commission has not issued any stop order or other order suspending the effectivenessof any registration statement filed by the Company or any Subsidiary under the Exchange Act or the Act.

(q) LaborRelations. No labor dispute exists or, to the knowledge of the Company, is imminent with respect to any of the employees of the Company,which could reasonably be expected to result in a Material Adverse Effect. Except as set forth in the SEC Reports, none of the Company’sor its Subsidiaries’ employees is a member of a union that relates to such employee’s relationship with the Company or suchSubsidiary, and neither the Company nor any of its Subsidiaries is a party to a collective bargaining agreement, and the Company and itsSubsidiaries believe that their relationships with their employees are good. To the knowledge of the Company, no executive officer ofthe Company or any Subsidiary, is, or is now expected to be, in violation of any material term of any employment contract, confidentiality,disclosure or proprietary information agreement or non-competition agreement, or any other contract or agreement or any restrictive covenantin favor of any third party, and, to the knowledge of the Company, the continued employment of each such executive officer does not subjectthe Company or any of its Subsidiaries to any liability with respect to any of the foregoing matters. The Company and its Subsidiariesare in compliance in all material respects with all applicable U.S. federal, state, local, Israeli and other non-U.S. laws and regulationsrelating to employment and employment practices, terms and conditions of employment and wages and hours, except where the failure to bein compliance could not, individually or in the aggregate, reasonably be expected to have a Material Adverse Effect.

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(r) Compliance.Neither the Company nor any Subsidiary: (i) is in default under or in violation of (and no event has occurred that has not been waivedthat, with notice or lapse of time or both, would result in a default by the Company or any Subsidiary under), nor has the Company orany Subsidiary received notice of a claim that it is in default under or that it is in violation of, any indenture, loan or credit agreementor any other agreement or instrument to which it is a party or by which it or any of its properties is bound (whether or not such defaultor violation has been waived), (ii) is in violation of any judgment, decree or order of any court, arbitrator or other governmental authorityor (iii) is or has been in violation of any statute, rule, ordinance or regulation of any governmental authority, including without limitationall foreign, federal, state, local, Israeli and other non-U.S. laws relating to taxes, environmental protection, occupational health andsafety, product quality and safety and employment and labor matters, except in each case of (i), (ii) and (iii) as could not have or reasonablybe expected to result in a Material Adverse Effect.

(s) EnvironmentalLaws. The Company and its Subsidiaries (i) are in compliance in all material respects with all federal, state, local, Israeli orother non-U.S. laws relating to pollution or protection of human health or the environment (including ambient air, surface water, groundwater,land surface or subsurface strata), including laws relating to emissions, discharges, releases or threatened releases of chemicals, pollutants,contaminants, or toxic or hazardous substances or wastes (collectively, “Hazardous Materials”) into the environment,or otherwise relating to the manufacture, processing, distribution, use, treatment, storage, disposal, transport or handling of HazardousMaterials, as well as all authorizations, codes, decrees, demands, or demand letters, injunctions, judgments, licenses, notices or noticeletters, orders, permits, plans or regulations, issued, entered, promulgated or approved thereunder (“Environmental Laws”);(ii) have received all permits licenses or other approvals required of them under applicable Environmental Laws to conduct their respectivebusinesses; and (iii) are in compliance in all material respects with all terms and conditions of any such permit, license or approvalwhere in each clause (i), (ii) and (iii), the failure to so comply could be reasonably expected to have, individually or in the aggregate,a Material Adverse Effect.

(t) RegulatoryPermits. The Company and the Subsidiaries possess all certificates, authorizations and permits issued by the appropriate federal,state, local, Israeli or other non-U.S. governmental or regulatory authorities necessary to conduct their respective businesses as describedin the SEC Reports, except where the failure to possess such permits could not reasonably be expected to result in a Material AdverseEffect (“Material Permits”), and neither the Company nor any Subsidiary has received any notice of proceedings relatingto the revocation or modification of any Material Permit. The Company has not engaged in any form of solicitation, advertising or otheraction constituting an offer or a sale under the Israeli Securities Law, 5728-1968 and the regulations promulgated thereunder in connectionwith the transactions contemplated hereby, which would require the Company to publish a prospectus in the State of Israel under the lawsof the State of Israel.

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(u) Titleto Assets. The Company and the Subsidiaries have good and marketable title in fee simple to all real property owned by them and goodand marketable title in all personal property owned by them that is material to the business of the Company and the Subsidiaries, in eachcase free and clear of all Liens, except for (i) Liens as do not materially affect the value of such property and do not materially interferewith the use made and proposed to be made of such property by the Company and the Subsidiaries and (ii) Liens for the payment of federal,state, Israeli, non-U.S. or other taxes, for which appropriate reserves have been made therefor in accordance with GAAP and, the paymentof which is neither delinquent nor subject to penalties. Any real property and facilities held under lease by the Company and the Subsidiariesare held by them under valid, subsisting and enforceable leases with which the Company and the Subsidiaries are in material compliance.

(v) IntellectualProperty. The Company and the Subsidiaries have, or have rights to use, all patents, patent applications, trademarks, trademark applications,service marks, trade names, trade secrets, inventions, copyrights, licenses and other intellectual property rights and similar rightsnecessary or required for use in connection with their respective businesses as described in the SEC Reports and which the failure toso have could have a Material Adverse Effect (collectively, the “Intellectual Property Rights”). None of, and neitherthe Company nor any Subsidiary has received a notice (written or otherwise) that any of, the Intellectual Property Rights has expired,terminated or been abandoned, or is expected to expire or terminate or be abandoned, within two (2) years from the date of this Agreement,except as would not be reasonably expected to have a Material Adverse Effect. Except as set forth in the SEC Reports, neither the Companynor any Subsidiary has received, since the date of the latest audited financial statements included within the SEC Reports, a writtennotice of a claim or otherwise has any knowledge that the Intellectual Property Rights violate or infringe upon the rights of any Person,except as could not have or reasonably be expected to not have a Material Adverse Effect. To the knowledge of the Company, all such IntellectualProperty Rights are enforceable and there is no existing infringement by another Person of any of the Intellectual Property Rights. TheCompany and its Subsidiaries have taken reasonable security measures to protect the secrecy, confidentiality and value of all of theirintellectual properties, except where failure to do so could not, individually or in the aggregate, reasonably be expected to have a MaterialAdverse Effect. The Company has no knowledge of any facts that would preclude it from having valid license rights or clear title to theIntellectual Property rights. The Company has no knowledge that it lacks or will be unable to obtain any rights or licenses to use allIntellectual Property Rights that are necessary to conduct its business.

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(w) Insurance.The Company and the Subsidiaries are insured by insurers of recognized financial responsibility against such losses and risks and in suchamounts as are prudent and customary in the businesses in which the Company and the Subsidiaries are engaged, including, but not limitedto, directors and officers insurance coverage. Neither the Company nor any Subsidiary has any reason to believe that it will not be ableto renew its existing insurance coverage as and when such coverage expires or to obtain similar coverage from similar insurers as maybe necessary to continue its business without a significant increase in cost.

(x) AffiliateTransactions. Except as set forth in the SEC Reports, none of the officers or directors of the Company or any Subsidiary and, to theknowledge of the Company, none of the employees of the Company or any Subsidiary is presently a party to any transaction with the Companyor any Subsidiary (other than for services as employees, officers and directors), including any contract, agreement or other arrangementproviding for the furnishing of services to or by, providing for rental of real or personal property to or from, providing for the borrowingof money from or lending of money to or otherwise requiring payments to or from any officer, director or such employee or, to the knowledgeof the Company, any entity in which any officer, director, or any such employee has a substantial interest or is an officer, director,trustee, shareholder, member or partner, in each case in excess of $120,000 other than for (i) payment of salary or consulting fees forservices rendered, (ii) reimbursem*nt for expenses incurred on behalf of the Company and (iii) other employee benefits, including shareoption agreements under any share option plan of the Company.

(y) SarbanesOxley Compliance. The Company and the Subsidiaries are in compliance in all material respects with any and all applicable requirementsof the Sarbanes-Oxley Act of 2002, as amended, that are effective as of the date hereof, and any and all applicable rules and regulationspromulgated by the Commission thereunder that are effective as of the date hereof. The Company and the Subsidiaries maintain a systemof internal accounting controls sufficient to provide reasonable assurance that: (i) transactions are executed in accordance with management’sgeneral or specific authorizations, (ii) transactions are recorded as necessary to permit preparation of financial statements in conformitywith GAAP and to maintain asset accountability, (iii) access to assets is permitted only in accordance with management’s generalor specific authorization, and (iv) the recorded accountability for assets is compared with the existing assets at reasonable intervalsand appropriate action is taken with respect to any differences. The Company and the Subsidiaries have established disclosure controlsand procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) for the Company and the Subsidiaries and designed such disclosurecontrols and procedures to ensure that information required to be disclosed by the Company in the reports it files or submits under theExchange Act is recorded, processed, summarized and reported, within the time periods specified in the Commission’s rules and forms.The Company’s certifying officers have evaluated the effectiveness of the disclosure controls and procedures of the Company andthe Subsidiaries as of the end of the period covered by the most recently filed Form 20-F under the Exchange Act (such date, the “EvaluationDate”), and the disclosure controls and procedures are effective in all material respects to perform the functions for whichthey were established. The Company presented in its most recently filed periodic report under the Exchange Act the conclusions of thecertifying officers about the effectiveness of the disclosure controls and procedures based on their evaluations as of the EvaluationDate. Since the Evaluation Date, to the Company's knowledge, there have been no significant deficiencies or material weaknesses in theCompany's internal control over financial reporting (whether or not remediated) and no change in the Company's internal control over financialreporting that has materially affected, or is reasonably likely to materially affect, the Company's internal control over financial reporting.Since the Evaluation Date, there have been no changes in the internal control over financial reporting (as such term is defined in theExchange Act) of the Company and its Subsidiaries that have materially affected, or is reasonably likely to materially affect, the internalcontrol over financial reporting of the Company and its Subsidiaries.

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(z) CertainFees. Other than payments to be made to the Manager, no brokerage or finder’s fees or commissions are or will be payable bythe Company or any Subsidiary to any broker, financial advisor or consultant, finder, placement agent, investment banker, bank or otherPerson with respect to the transactions contemplated by this Agreement. The Manager shall have no obligation with respect to any feesor with respect to any claims made by or on behalf of other Persons for fees of a type contemplated in this Section that may be due inconnection with the transactions contemplated by this Agreement.

(aa) No OtherSales Agency Agreement. The Company has not entered into any other sales agency agreements or other similar arrangements with anyagent or any other representative in respect of at the market offerings of the Ordinary Shares or Ordinary Shares represented by ADSs.

(bb) InvestmentCompany. The Company is not, and is not an Affiliate of, and immediately after receipt of payment for the ADSs pursuant to thisAgreement, will not be or be an Affiliate of, an “investment company” within the meaning of the Investment Company Act of1940, as amended. The Company shall conduct its business in a manner so that it and its Subsidiaries will not become an “investmentcompany” subject to registration under the Investment Company Act of 1940, as amended.

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(cc) Listingand Maintenance Requirements. The ADSs are listed on the Trading Market and the sale and delivery of the ADSs as contemplated by thisAgreement does not contravene the rules and regulations of the Trading Market. The Ordinary Shares or Ordinary Shares represented by ADSsare registered pursuant to Section 12(b) or 12(g) of the Exchange Act, and the Company has taken no action designed to, or which to itsknowledge is likely to have the effect of, terminating the registration of the Ordinary Shares or Ordinary Shares represented by ADSsunder the Exchange Act nor has the Company received any notification that the Commission is contemplating terminating such registration.Except as set forth in the SEC Reports, the Company has not, in the 12 months preceding the date hereof, received notice from any TradingMarket on which the Ordinary Shares and/or ADSs are or have been listed or quoted to the effect that the Company is not in compliancewith the listing or maintenance requirements of such Trading Market. The Company is, and has no reason to believe that it will not inthe foreseeable future continue to be, in compliance with all such listing and maintenance requirements. The ADSs are currently eligiblefor electronic transfer through the Depository Trust Company or another established clearing corporation and the Company is current inpayment of the fees to the Depositary and the Depository Trust Company (or such other established clearing corporation) in connectionwith such electronic transfer.

(dd) [RESERVED]

(ee) Solvency.Based on the consolidated financial condition of the Company as of the date hereof, (i) the fair saleable value of the Company’sassets exceeds the amount that will be required to be paid on or in respect of the Company’s existing debts and other liabilities(including known contingent liabilities) as they mature, (ii) the Company’s assets do not constitute unreasonably small capitalto carry on its business as now conducted and as proposed to be conducted including its capital needs taking into account the particularcapital requirements of the business conducted by the Company, consolidated and projected capital requirements and capital availabilitythereof, and (iii) the current cash flow of the Company, together with the proceeds the Company would receive, were it to liquidate allof its assets, after taking into account all anticipated uses of the cash, would be sufficient to pay all amounts on or in respect ofits liabilities when such amounts are required to be paid. The Company does not intend to incur debts beyond its ability to pay such debtsas they mature (taking into account the timing and amounts of cash to be payable on or in respect of its debt) within one year from thedate hereof. The Company has no knowledge of any facts or circ*mstances which lead it to believe that it will file for reorganizationor liquidation under the bankruptcy or reorganization laws of any jurisdiction within one year from the date hereof. The SEC Reports setforth as of the date hereof all outstanding secured and unsecured Indebtedness of the Company or any Subsidiary, or for which the Companyor any Subsidiary has commitments. For the purposes of this Agreement, “Indebtedness” means (x) any liabilities forborrowed money or amounts owed in excess of $100,000 (other than trade accounts payable incurred in the ordinary course of business),(y) all guaranties, endorsem*nts and other contingent obligations in respect of indebtedness of others, whether or not the same are orshould be reflected in the Company’s consolidated balance sheet (or the notes thereto), except guaranties by endorsem*nt of negotiableinstruments for deposit or collection or similar transactions in the ordinary course of business; and (z) the present value of any leasepayments in excess of $100,000 due under leases required to be capitalized in accordance with GAAP. Except as set forth in the SEC Reports,neither the Company nor any Subsidiary is in default with respect to any Indebtedness.

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(ff) Tax Status.Except for matters that would not, individually or in the aggregate, have or reasonably be expected to result in a Material Adverse Effect,the Company and its Subsidiaries each (i) has made or filed, or has received timely extension thereof, all United States federal, state,local, Israeli and other non-U.S. income and all foreign income and franchise tax returns, reports and declarations required by any jurisdictionto which it is subject, (ii) has paid all taxes and other governmental assessments and charges that are material in amount, shown or determinedto be due on such returns, reports and declarations and (iii) has set aside on its books provision reasonably adequate for the paymentof all material taxes for periods subsequent to the periods to which such returns, reports or declarations apply. There are no unpaidtaxes in any material amount claimed to be due by the taxing authority of any jurisdiction, and the officers of the Company or of anySubsidiary know of no basis for any such claim.

(gg) ForeignCorrupt Practices. Neither the Company nor any Subsidiary, nor to the knowledge of the Company or any Subsidiary, any agent or otherperson acting on behalf of the Company or any Subsidiary, has (i) directly or indirectly, used any funds for unlawful contributions, gifts,entertainment or other unlawful expenses related to foreign or domestic political activity, (ii) made any unlawful payment to foreignor domestic government officials or employees or to any foreign or domestic political parties or campaigns from corporate funds, (iii)failed to disclose fully any contribution made by the Company or any Subsidiary (or made by any person acting on its behalf of which theCompany is aware) which is in violation of law, or (iv) violated in any material respect any provision of the Foreign Corrupt PracticesAct of 1977, as amended, or any applicable law or regulation implementing the OECD Convention on Combating Bribery of Foreign Public Officialsin International Business Transactions, or committed an offence under the Bribery Act 2010 of the United Kingdom or any other applicableanti-bribery or any other applicable anti-corruption law, including, without limitation, Section 291A of the Israel Penal Law 5737-1977and the rules and regulations thereunder.

(hh) Accountants.The Company's accounting firm is set forth in the SEC Reports. To the knowledge and belief of the Company, such accounting firm (i) isa registered public accounting firm as required by the Exchange Act and the rules of the Public Company Accounting Oversight Board ("PCAOB"),(ii) has expressed its opinion with respect to the financial statements included in the Company's Annual Report for the fiscal year endedDecember 31, 2023, (iii) is in compliance with the applicable requirements relating to the qualification of accountants under Rule 2-01of Regulation S-X under the Act and (iv) a registered public accounting firm as defined by PCAOB whose registration has not been suspendedor revoked and who has not requested such registration to be withdrawn.

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(ii) RegulationM Compliance. The Company has not, and to its knowledge no one acting on its behalf has, (i) taken, directly or indirectly,any action designed to cause or to result in the stabilization or manipulation of the price of any security of the Company to facilitatethe sale or resale of any of the Ordinary Shares or ADSs, (ii) sold, bid for, purchased, or, paid any compensation for soliciting purchasesof, any of the Ordinary Shares or ADSs, or (iii) paid or agreed to pay to any Person any compensation for soliciting another to purchaseany other securities of the Company, other than, in the case of clauses (ii) and (iii), compensation paid to the Manager in connectionwith the sale of the ADSs hereunder.

(jj) FDA.As to each product subject to the jurisdiction of the U.S. Food and Drug Administration (“FDA”) under the Federal Food,Drug and Cosmetic Act, as amended, and the regulations thereunder (“FDCA”) that is manufactured, packaged, labeled,tested, distributed, sold, and/or marketed by the Company or any of its Subsidiaries (each such product, a “Pharmaceutical Product”),such Pharmaceutical Product is being manufactured, packaged, labeled, tested, distributed, sold and/or marketed by the Company in compliancewith all applicable requirements under FDCA and similar laws, rules and regulations relating to registration, investigational use, premarketclearance, licensure, or application approval, good manufacturing practices, good laboratory practices, good clinical practices, productlisting, quotas, labeling, advertising, record keeping and filing of reports, except where the failure to be in compliance would not havea Material Adverse Effect. There is no pending, completed or, to the Company's knowledge, threatened, action (including any lawsuit, arbitration,or legal or administrative or regulatory proceeding, charge, complaint, or investigation) against the Company or any of its Subsidiaries,and none of the Company or any of its Subsidiaries has received any notice, warning letter or other communication from the FDA or anyother governmental entity, which (i) contests the premarket clearance, licensure, registration, or approval of, the uses of, the distributionof, the manufacturing or packaging of, the testing of, the sale of, or the labeling and promotion of any Pharmaceutical Product, (ii)withdraws its approval of, requests the recall, suspension, or seizure of, or withdraws or orders the withdrawal of advertising or salespromotional materials relating to, any Pharmaceutical Product, (iii) imposes a clinical hold on any clinical investigation by the Companyor any of its Subsidiaries, (iv) enjoins production at any facility of the Company or any of its Subsidiaries, (v) enters or proposesto enter into a consent decree of permanent injunction with the Company or any of its Subsidiaries, or (vi) otherwise alleges any violationof any laws, rules or regulations by the Company or any of its Subsidiaries, and which, either individually or in the aggregate, wouldhave a Material Adverse Effect. The properties, business and operations of the Company have been and are being conducted in all materialrespects in accordance with all applicable laws, rules and regulations of the FDA. The Company has not been informed by the FDAthat the FDA will prohibit the marketing, sale, license or use in the United States of any product proposed to be developed, producedor marketed by the Company nor has the FDA expressed any concern as to approving or clearing for marketing any product being developedor proposed to be developed by the Company.

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(kk) ShareOption Plans. With respect to the share options (the "Share Options") granted pursuant to the share-based compensationplans of the Company and its subsidiaries (the "Company Share Plans"), (i) each Share Option purported to be issued underSection 102 of the Israeli Tax Ordinance - (New Version) 1961 qualifies for treatment under that section and for treatment under eitherthe capital gains track or the employment income track, as was indicated with respect to each such Share Option at the date that suchShare Option was granted, except as would not reasonably be expected to result in a Material Adverse Effect, (ii) each Share Option intendedto qualify as an "incentive stock option" under Section 422 of the Code (as defined below) so qualifies, except as would notreasonably be expected to result in a Material Adverse Effect, (iii) each grant of a Share Option was duly authorized no later than thedate on which the grant of such Share Option was by its terms to be effective (the "Grant Date") by all necessary corporateaction, including, as applicable, approval by the Board (or a duly constituted and authorized committee thereof) and any required shareholderapproval, and the award agreement governing such grant (if any) was duly executed and delivered by each party thereto, (iv) each suchgrant was made in accordance with the terms of the Company Share Plans and all other applicable laws and regulatory rules or requirements,and (v) each such grant was properly accounted for in accordance with GAAP in the financial statements (including the related notes) ofthe Company included in the Registration Statement and Prospectus.

(ll) Cybersecurity.(i)(x) There has been no security breach or other compromise of or relating to any of the Company’s or any Subsidiary’s informationtechnology and computer systems, networks, hardware, software, data (including the data of its respective customers, employees, suppliers,vendors and any third party data maintained by or on behalf of it), equipment or technology (collectively, “IT Systems and Data”),except as would not, individually or in the aggregate, have a Material Adverse Effect, and (y) the Company and the Subsidiaries have notbeen notified of, and has no knowledge of any event or condition that would reasonably be expected to result in, any material securitybreach or other compromise to its IT Systems and Data; (ii) the Company and the Subsidiaries are presently in compliance in all materialrespects with all applicable laws or statutes (including, but not limited to, the European Union General Data Protection Regulation andthe Israeli Privacy Protection Regulations, Information, Security, 2017) and all applicable judgments, orders, rules and regulations ofany court or arbitrator or governmental or regulatory authority, internal policies and contractual obligations relating to the privacyand security of IT Systems and Data and to the protection of such IT Systems and Data from unauthorized use, access, misappropriationor modification, except as would not, individually or in the aggregate, have a Material Adverse Effect; (iii)the Company and theSubsidiaries have implemented and maintained commercially reasonable safeguards to maintain and protect its material confidential informationand the integrity, continuous operation, redundancy and security of all IT Systems and Data; and (iv) the Company and the Subsidiarieshave implemented backup and disaster recovery technology consistent with industry standards and practices.

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(mm) Compliancewith Data Privacy Laws. (i)The Company and the Subsidiaries are, and at all times during the past three years were, in compliancewith all applicable data privacy and security laws and regulations, including, as applicable, the European Union General Data ProtectionRegulation (“GDPR”) (EU 2016/679) and Israeli Privacy Protection Regulations, Information, Security, 2017 (collectively,“Privacy Laws”); (ii)the Company and the Subsidiaries have in place, comply with, and take appropriate stepsreasonably designed to ensure compliance with their policies and procedures relating to data privacy and security and the collection,storage, use, disclosure, handling and analysis of Personal Data (the “Policies”); (iii)the Company providesaccurate notice of its applicable Policies to its customers, employees, third party vendors and representatives as required by PrivacyLaws; and (iv)applicable Policies provide accurate and sufficient notice of the Company’s then-current privacy practices relatingto its subject matter, and do not contain any material omissions of the Company’s then-current privacy practices, as required byPrivacy Laws.“Personal Data” means (i)a natural person’s name, street address, telephone number,email address, photograph, social security number, bank information, or customer or account number; (ii)any information which wouldqualify as “personally identifying information” under the Federal Trade Commission Act, as amended; (iii) “personaldata” as defined by GDPR; and (iv)any other piece of information that allows the identification of such natural person, orhis or her family, or permits the collection or analysis of any identifiable data related to an identified person’s health or sexualorientation. (i)None of such disclosures made or contained in any of the Policies have been inaccurate, misleading, or deceptivein violation of any Privacy Laws and (ii)the execution, delivery and performance of this Agreement will not result in a breach ofany Privacy Laws or Policies. Neither the Company nor the Subsidiaries, (i)has, to the knowledge of the Company, receivedwritten notice of any actual or potential liability of the Company or the Subsidiaries under, or actual or potential violation by theCompany or the Subsidiaries of, any of the Privacy Laws; (ii)is currently conducting or paying for, in whole or in part, any investigation,remediation or other corrective action pursuant to any regulatory request or demand pursuant to any Privacy Law; or (iii)is a partyto any order, decree, or agreement by or with any court or arbitrator or governmental or regulatory authority that imposed any obligationor liability under any Privacy Law.

(nn) Officeof Foreign Assets Control. Neither the Company nor any of its Subsidiaries, nor to the knowledge of the Company, any of the directors,officers or employees of the Company or its Subsidiaries, is an individual or entity that is, or is owned or controlled by an individualor entity that is: (i)the subject of any sanctions administered or enforced by the U.S. Department of Treasury’s Office ofForeign Assets Control, the United Nations Security Council, the European Union, His Majesty’s Treasury, or other relevant sanctionsauthority, including by virtue of similar laws or rules of the State of Israel (collectively, “Sanctions”), nor (ii)located,organized or resident in a country or territory that is the subject of Sanctions. Neither the Company nor any of its Subsidiaries will,directly or indirectly, use the proceeds of the transactions contemplated hereby, or lend, contribute or otherwise make available suchproceeds to any Subsidiary, joint venture partner or other Person: (i)to fund or facilitate any activities or business of or withany Person or in any country or territory that, at the time of such funding or facilitation, is the subject of Sanctions or (ii)inany other manner that will result in a violation of Sanctions by any Person (including any Person participating in the transactions contemplatedhereby, whether as underwriter, advisor, investor or otherwise). For the past five years, neither the Company nor any of its Subsidiarieshas knowingly engaged in, and is not now knowingly engaged in, any dealings or transactions with any Person, or in any country or territory,that at the time of the dealing or transaction is or was the subject of Sanctions.

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(oo) U.S.Real Property Holding Corporation. The Company is not and has never been a U.S. real property holding corporation within the meaningof Section 897 of the Internal Revenue Code of 1986, as amended, and the Company shall so certify upon the Manager’s request.

(pp) BankHolding Company Act. Neither the Company nor any of its Subsidiaries or Affiliates is subject to the Bank Holding Company Act of 1956,as amended (the “BHCA”) and to regulation by the Board of Governors of the Federal Reserve System (the “FederalReserve”). Neither the Company nor any of its Subsidiaries or Affiliates owns or controls, directly or indirectly, five percent(5%) or more of the outstanding shares of any class of voting securities or twenty-five percent (25%) or more of the total equity of abank or any entity that is subject to the BHCA and to regulation by the Federal Reserve. Neither the Company nor any of its Subsidiariesor Affiliates exercises a controlling influence over the management or policies of a bank or any entity that is subject to the BHCA andto regulation by the Federal Reserve.

(qq) MoneyLaundering. The operations of the Company and its Subsidiaries are and have been conducted at all times in compliance with applicablefinancial record-keeping and reporting requirements of the Currency and Foreign Transactions Reporting Act of 1970, as amended, the moneylaundering statutes of all jurisdictions where the Company or any of its Subsidiaries conducts business including the Israel Prohibitionon Money Laundering Law, 5760-2000, Israel Prohibition on Money Laundering Order, 5761-2001 and the Israel Prohibition on Terrorist FinancingLaw, 5765-2005, any applicable money laundering statutes and applicable rules and regulations thereunder (collectively, the “MoneyLaundering Laws”), and no Action or Proceeding by or before any court or governmental agency, authority or body or any arbitratorinvolving the Company or any Subsidiary with respect to the Money Laundering Laws is pending or, to the knowledge of the Company or anySubsidiary, threatened.

(rr) FINRAMember Shareholders. There are no affiliations with any FINRA member firm among the Company’s officers, directors or, to theknowledge of the Company, any five percent (5%) or greater shareholder of the Company, except as set forth in the Registration Statement,the Base Prospectus, any Prospectus Supplement or the Prospectus.

(ss) ERISACompliance. Except as otherwise disclosed in the Registration Statement and the Prospectus, the Company and its Subsidiaries and any"employee benefit plan" (as defined under the Employee Retirement Income Security Act of 1974, as amended, and the regulationsand published interpretations thereunder (collectively, "ERISA")) established or maintained by the Company, its Subsidiariesor their "ERISA Affiliates" (as defined below) are in compliance in all material respects with ERISA. "ERISA Affiliate"means, with respect to the Company or any of its Subsidiaries, any member of any group of organizations described in Sections 414(b),(c), (m) or (o) of the Internal Revenue Code of 1986, as amended, and the regulations and published interpretations thereunder (the "Code")of which the Company or such Subsidiary is a member. No "reportable event" (as defined under ERISA) has occurred or is reasonablyexpected to occur with respect to any "employee benefit plan" established or maintained by the Company, its Subsidiaries orany of their ERISA Affiliates. No "employee benefit plan" established or maintained by the Company, its Subsidiaries or anyof their ERISA Affiliates, if such "employee benefit plan" were terminated, would have any "amount of unfunded benefitliabilities" (as defined under ERISA). Neither the Company, its Subsidiaries nor any of their ERISA Affiliates has incurred or reasonablyexpects to incur any liability under (i) Title IV of ERISA with respect to termination of, or withdrawal from, any "employee benefitplan" or (ii) Sections 412, 4971, 4975 or 4980B of the Code. Each "employee benefit plan" established or maintained bythe Company, its subsidiaries or any of their ERISA Affiliates that is intended to be qualified under Section 401(a) of the Code is soqualified and nothing has occurred, whether by action or failure to act, which would cause the loss of such qualification.

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(tt) Authorizationof the Deposit Agreement. The Deposit Agreement has been duly authorized, executed and delivered by the Company and constitutes alegal, valid and binding agreement of the Company, enforceable against the Company in accordance with its terms, except as enforcementthereof may be limited by bankruptcy, insolvency, fraudulent transfer, reorganization, moratorium and similar laws of general applicabilityrelating to or affecting creditors' rights and to general principles of equity; upon due issuance by the Depositary of ADSs against thedeposit of the Ordinary Shares in respect thereof in accordance with the Deposit Agreement, such ADSs sold hereunder will be duly andvalidly issued and the owners and holders thereof will be entitled to the rights specified therein and in the Deposit Agreement; and theDeposit Agreement and the ADSs conform in all material respects to the descriptions thereof contained in the Prospectus.

(uu) Forward-LookingStatements. Each financial or operational projection or other "forward-looking statement" (as defined by Section 27A ofthe Act or Section 21E of the Exchange Act) contained in the Registration Statement or the Prospectus (i) was so included by the Companyin good faith and with reasonable basis after due consideration by the Company of the underlying assumptions, estimates and other applicablefacts and circ*mstances and (ii) as required, is accompanied by meaningful cautionary statements identifying those factors that couldcause actual results to differ materially from those in such forward-looking statement. No such statement was made that was false or misleadingwith the knowledge of a director or senior manager of the Company that it was false or misleading.

(vv) IsraeliTax Benefits. (i) The Company is in compliance with all conditions and requirements stipulated by the instruments of approval andtax ruling (the "Ruling") granted to it with respect to "Benefited Enterprise" ("Tax Incentive Program")status of the Company and/or any of its facilities as well as with respect to the other tax benefits received by the Company as set forthunder the caption "Israeli Tax Considerations and Government Programs" in the Registration Statement and the Prospectus andby Israeli laws and regulations relating to its Tax Incentive Program and the aforementioned other tax benefits received by the Company;(ii) all information supplied by the Company with respect to applications relating to its Tax Incentive Program (including in connectionwith the Ruling) was true, correct and complete when supplied to the appropriate authorities; and (iii) the Company has not received anynotice of any proceeding or investigation relating to revocation or modification of any of its current or past Tax Incentive Program grantedwith respect to the Company and/or any of its facilities, in each case except for any failure to comply, inaccuracy or notice (as appropriate)that would not, individually or in the aggregate, reasonably be expected to have a Material Adverse Effect.

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(ww) No Immunity.Neither the Company nor any of its Subsidiaries or their properties or assets has immunity under the State of Israel, U.S. federal orNew York state law from any legal action, suit or proceeding, from the giving of any relief in any such legal action, suit or proceeding,from set-off or counterclaim, from the jurisdiction of the State of Israel, U.S. federal or New York state court, from service of process,attachment upon or prior to judgment, or attachment in aid of execution of judgment, or from execution of a judgment, or other legal processor proceeding for the giving of any relief or for the enforcement of a judgment, in any such court with respect to their respective obligations,liabilities or any other matter under or arising out of or in connection herewith; and, to the extent that the Company or any of its subsidiariesor any of its properties, assets or revenues may have or may hereafter become entitled to any such right of immunity in any such courtin which proceedings arising out of, or relating to the transactions contemplated by this Agreement, may at any time be commenced, theCompany has, pursuant to this Agreement, waived, and it will waive, or will cause its Subsidiaries to waive, such right to the extentpermitted by law.

(xx) Enforcementof Foreign Judgments. Any final judgment for a fixed or determined sum of money rendered by any U.S. federal or New York state courtlocated in the State of New York having jurisdiction under its own laws in respect of any suit, action or proceeding against the Companybased upon this Agreement are enforceable against the Company by the courts of the State of Israel, without reconsideration or reexaminationof the merits, subject to the limitations described in the Registration Statement and the Prospectus under "Enforceability of CivilLiabilities."

(yy) ValidChoice of Law. The choice of laws of the State of New York as the governing law of this Agreement is a valid choice of law under thelaws of the State of Israel and would be enforceable by the courts of the State of Israel, subject to the restrictions described underthe caption "Enforceability of Civil Liabilities" in the Registration Statement and the Prospectus. The Company has the powerto submit, and pursuant to Section 16 of this Agreement, has legally, validly, effectively and irrevocably submitted, to the personaljurisdiction of each New York state and United States federal court sitting in the City of New York and has validly and irrevocably waivedany objection to the laying of venue of any suit, action or proceeding brought in such court.

(zz) Indemnificationand Contribution. The indemnification and contribution provisions set forth in Section 7 hereof do not contravene Israeli law or publicpolicy.

(aaa) Dividends.Except as disclosed in the Registration Statement and the Prospectus, (i) no approvals are currently required under the laws of the Stateof Israel in order for the Company to pay dividends or other distributions declared by the Company to the holders of Shares assuming theCompany has sufficient profits for distribution under the Companies Law, and (ii) under current laws and regulations of the State of Israel,any amount payable with respect to the Shares upon liquidation of the Company or upon redemption thereof and dividends and other distributionsdeclared and payable on the share capital of the Company may be paid by the Company in United States dollars or euros and freely transferredout of the State of Israel, subject to payment of applicable withholding taxes or an exemption therefrom.

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(bbb) LegalAction. A holder of the ADSs and the Manager are each entitled to sue as plaintiff in the court of the jurisdiction of formation anddomicile of the Company for the enforcement of their respective rights under this Agreement and the ADSs and such access to such courtswill not be subject to any conditions which are not applicable to residents of such jurisdiction or a company incorporated in such jurisdictionexcept that plaintiffs not residing in the State of Israel may be required to guarantee payment of a possible order for payment of costsor damages at the request of the defendant.

(ccc) ForeignIssuer. The Company is a "foreign private issuer" as defined in Rule 405 under the Securities Act.

(ddd) EmergingGrowth Company. The Company has been and is an "emerging growth company," as defined in Section 2(a) of the Securities Act(an "Emerging Growth Company").

4. Agreements.The Company agrees with the Manager that:

(a) Rightto Review Amendments and Supplements to Registration Statement and Prospectus. During any period when the delivery of a prospectusrelating to the ADSs is required (including in circ*mstances where such requirement may be satisfied pursuant to Rule172, 173 orany similar rule) to be delivered under the Act in connection with the offering or the sale of ADSs, the Company will not file any amendmentto the Registration Statement or supplement (including any Prospectus Supplement, but excluding any annual report of the Company filedpursuant to Section 13(a) or 15(d) of the Exchange Act) to the Base Prospectus unless the Company has furnished to the Manager a copyfor its review prior to filing and will not file any such proposed amendment or supplement to which the Manager reasonably objects (provided,however, that the Company will have no obligation to provide the Manager any advance copy of such filing or to provide the Manager anopportunity to object to such filing if the filing does not name the Manager and does not relate to the transactions under this Agreement).The Company has properly completed the Prospectus, in a form approved by the Manager, and filed such Prospectus, as amended at the ExecutionTime, with the Commission pursuant to the applicable paragraph of Rule424(b) by the Execution Time and will cause any supplementto the Prospectus to be properly completed, in a form approved by the Manager, and will file such supplement with the Commission pursuantto the applicable paragraph of Rule424(b) within the time period prescribed thereby and will provide evidence reasonably satisfactoryto the Manager of such timely filing. The Company will promptly advise the Manager (i)when the Prospectus, and any supplement thereto,shall have been filed (if required) with the Commission pursuant to Rule424(b), (ii)when, during any period when the deliveryof a prospectus (whether physically or through compliance with Rule172, 173 or any similar rule) is required under the Act in connectionwith the offering or sale of the Ordinary Shares or ADSs, any amendment to the Registration Statement shall have been filed or becomeeffective (other than any annual report of the Company filed pursuant to Section 13(a) or 15(d) of the Exchange Act), (iii)of anyrequest by the Commission or its staff for any amendment of the Registration Statement, or for any supplement to the Prospectus or forany additional information, (iv)of the issuance by the Commission of any stop order suspending the effectiveness of the RegistrationStatement or of any notice objecting to its use or the institution or threatening of any proceeding for that purpose and (v)of thereceipt by the Company of any notification with respect to the suspension of the qualification of the Ordinary Shares or ADSs for salein any jurisdiction or the institution or threatening of any proceeding for such purpose. The Company will use its commercially reasonablebest efforts to prevent the issuance of any such stop order or the occurrence of any such suspension or objection to the use of the RegistrationStatement and, upon such issuance, occurrence or notice of objection, to obtain as soon as possible the withdrawal of such stop orderor relief from such occurrence or objection, including, if necessary, by filing an amendment to the Registration Statement or a new registrationstatement and using its commercially reasonable efforts to have such amendment or new registration statement declared effective as soonas practicable.

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(b) SubsequentEvents. If, at any time on or after an Applicable Time but prior to the related Settlement Date, any event occurs as a result of whichthe Registration Statement or Prospectus would include any untrue statement of a material fact or omit to state any material fact necessaryto make the statements therein in the light of the circ*mstances under which they were made or the circ*mstances then prevailing not misleading,the Company will (i)notify promptly the Manager so that any use of the Registration Statement or Prospectus may cease until suchare amended or supplemented; (ii)amend or supplement the Registration Statement or Prospectus to correct such statement or omission;and (iii)supply any such amendment or supplement to the Manager in such quantities as the Manager may reasonably request.

(c) Notificationof Subsequent Filings. During any period when the delivery of a prospectus relating to the ADSs is required (including in circ*mstanceswhere such requirement may be satisfied pursuant to Rule172, 173 or any similar rule) to be delivered under the Act, any event occursas a result of which the Prospectus as then supplemented would include any untrue statement of a material fact or omit to state any materialfact necessary to make the statements therein in the light of the circ*mstances under which they were made not misleading, or if it shallbe necessary to amend the Registration Statement, file a new registration statement or supplement the Prospectus to comply with the Actor the Exchange Act or the respective rules thereunder, including in connection with use or delivery of the Prospectus, the Company promptlywill (i)notify the Manager of any such event (provided that such notification to the Manager shall not be required if a Sales Noticehas neither been delivered nor is pending at the time of such event, but such notification shall be required at least three (3) TradingDays prior to delivery by the Company of any Sales Notice to the Manager to sell ADSs hereunder), (ii)subject to Section 4(a), prepareand file with the Commission an amendment or supplement or new registration statement which will correct such statement or omission oreffect such compliance, (iii)use its commercially reasonable efforts to have any amendment to the Registration Statement or newregistration statement declared effective as soon as practicable in order to avoid any disruption in use of the Prospectus and (iv)supplyany supplemented Prospectus to the Manager in such quantities as the Manager may reasonably request.

(d) EarningsStatements. As soon as practicable, the Company will make generally available to its security holders and to the Manager an earningsstatement or statements of the Company and its Subsidiaries which will satisfy the provisions of Section11(a) of the Act and Rule158.For the avoidance of doubt, the Company’s compliance with the reporting requirements of the Exchange Act shall be deemed to satisfythe requirements of this Section 4(d).

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(e) Deliveryof Registration Statement. Upon the request of the Manager, the Company will furnish to the Manager and counsel for the Manager, withoutcharge, signed copies of the Registration Statement (including exhibits thereto) and, so long as delivery of a prospectus by the Manageror dealer may be required by the Act (including in circ*mstances where such requirement may be satisfied pursuant to Rule172, 173or any similar rule), as many copies of the Prospectus and each Issuer Free Writing Prospectus and any supplement thereto as the Managermay reasonably request. The Company will pay the expenses of printing or other production of all documents relating to the offering.

(f) Qualificationof ADSs. The Company will arrange, if necessary, for the qualification of the ADSs or Ordinary Shares for sale under the laws of suchjurisdictions as the Manager may designate and will maintain such qualifications in effect so long as required for the distribution ofthe ADSs; provided that in no event shall the Company be obligated to qualify to do business in any jurisdiction where it is not now soqualified or to take any action that would subject it to service of process in suits, other than those arising out of the offering orsale of the ADSs, in any jurisdiction where it is not now so subject.

(g) FreeWriting Prospectus. The Company agrees that, unless it has or shall have obtained the prior written consent of the Manager, and theManager agrees with the Company that, unless it has or shall have obtained, as the case may be, the prior written consent of the Company,it has not made and will not make any offer relating to the ADSs that would constitute an Issuer Free Writing Prospectus or that wouldotherwise constitute a “free writing prospectus” (as defined in Rule405) required to be filed by the Company with theCommission or retained by the Company under Rule433. Any such free writing prospectus consented to by the Manager or the Companyis hereinafter referred to as a “Permitted Free Writing Prospectus.” The Company agrees that (i)it has treatedand will treat, as the case may be, each Permitted Free Writing Prospectus as an Issuer Free Writing Prospectus and (ii)it has compliedand will comply, as the case may be, with the requirements of Rules164 and 433 applicable to any Permitted Free Writing Prospectus,including in respect of timely filing with the Commission, legending and record keeping.

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(h) SubsequentEquity Issuances. The Company shall not deliver any Sales Notice hereunder (and any Sales Notice previously delivered shall not applyduring such two (2) Trading Days) for at least two (2) Trading Days prior to any date on which the Company or any Subsidiary offers, sells,issues, contracts to sell, contracts to issue or otherwise disposes of, directly or indirectly, any other Ordinary Shares, ADSs or anyOrdinary Share Equivalents (other than the ADSs issuable pursuant to this Agreement), subject to Manager’s right to waive this obligation,provided that, without compliance with the foregoing obligation, the Company may issue (i) Ordinary Shares or ADSs or Ordinary Share Equivalentspursuant to any employee equity plan, share ownership plan or dividend reinvestment plan of the Company in effect from time to time and(iii) Ordinary Shares or ADSs issuable upon the conversion or exercise of Ordinary Share Equivalents outstanding from time to time, and(iii) ADSs, Ordinary Shares or any Ordinary Share Equivalents in a privately negotiated transactions to vendors, service providers, strategicpartners or potential strategic partners, provided that such issuances are not made for capital raising purposes and are conducted ina manner so as not to be integrated with the offering of ADSs hereby for purposes of Regulation M and to not constitute a distributionfor purposes of Regulation M.

(i) MarketManipulation. Until the termination of this Agreement, the Company will not take, directly or indirectly, any action designed to orthat would constitute or that might reasonably be expected to cause or result in, under the Exchange Act or otherwise, stabilization ormanipulation in violation of the Act, Exchange Act or the rules and regulations thereunder of the price of any security of the Companyto facilitate the sale or resale of the ADSs or otherwise violate any provision of Regulation M under the Exchange Act.

(j) Notificationof Incorrect Certificate. The Company will, at any time during the term of this Agreement, as supplemented from time to time, advisethe Manager immediately after it shall have received notice or obtained knowledge thereof, of any information or fact that would alteror affect any opinion, certificate, letter and other document provided to the Manager pursuant to Section6 herein.

(k) Certificationof Accuracy of Disclosure. Upon commencement of the offering of the ADSs under this Agreement (and upon the recommencement of theoffering of the ADSs under this Agreement following the termination of a suspension of sales hereunder lasting more than 30 Trading Days),and each time that (i) a new Registration Statement is filed and declared effective, (ii) the Registration Statement or Prospectus shallbe amended or supplemented, other than by means of Incorporated Documents, (iii) the Company files its Annual Report on Form 20-F underthe Exchange Act, (iv) the Company files a report on Form 6-K under the Exchange Act containing financial information for a six monthperiod, or the Company voluntarily files a report on Form 6-K under the Exchange Act containing financial information for a three monthperiod or a nine month period (v) the Company files a report on Form 6-K containing amended financial information (other than informationthat is furnished and not filed), if the Manager reasonably determines that the information in such Form 6-K is material, or (vi) theADSs are delivered to the Manager as principal at the Time of Delivery pursuant to a Terms Agreement (such commencement or recommencementdate and each such date referred to in (i), (ii), (iii), (iv), (v) and (vi) above, a “Representation Date”), unlesswaived by the Manager, the Company shall furnish or cause to be furnished to the Manager forthwith a certificate dated and delivered withinfive (5) Trading Days of the Representation Date, in form reasonably satisfactory to the Manager to the effect that the statements containedin the certificate referred to in Section 6 of this Agreement which were last furnished to the Manager are true and correct at the RepresentationDate, as though made at and as of such date (except that such statements shall be deemed to relate to the Registration Statement and theProspectus as amended and supplemented to such date) or, in lieu of such certificate, a certificate of the same tenor as the certificatereferred to in said Section 6, modified as necessary to relate to the Registration Statement and the Prospectus as amended and supplementedto the date of delivery of such certificate. Notwithstanding the foregoing, the requirement to furnish or cause to be furnished a certificateunder this Section 4(k) shall be waived for any Representation Date occurring at a time at which no instruction to the Manager to sellADSs pursuant to this Agreement has been delivered by the Company or is pending. Notwithstanding the foregoing, if the Company subsequentlydecides to sell ADSs following any Representation Date when the Company relied on such waiver and did not provide the Manager a certificatepursuant to this Section 4(k), then before the Company instructs the Manager to sell ADSs pursuant to this Agreement, the Company shallprovide the Manager such certificate to the extent required under this Section 4(k) and not previously delivered.

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(l) BringDown Opinions; Negative Assurance. Within five (5) Trading Days of each Representation Date, unless waived by the Manager, the Companyshall furnish or cause to be furnished forthwith to the Manager and to counsel to the Manager a written opinion of Company Israeli Counseland a written opinion of Company U.S. Counsel addressed to the Manager and dated and delivered within five (5) Trading Days of such RepresentationDate, in form and substance reasonably satisfactory to the Manager, including a negative assurance representation from Company U.S. Counsel.The requirement to furnish or cause to be furnished opinions (but not with respect to a negative assurance representation from US Counsel)under this Section 4(l) shall be waived for any Representation Date other than a new Registration Statement is filed and declared effectiveor a Representation Date on which a material amendment to the Registration Statement or Prospectus is made or the Company files its AnnualReport on Form 20-F or a material amendment thereto under the Exchange Act, unless the Manager reasonably requests such deliverable requiredby this Section 4(l) in connection with a Representation Date, upon which request such deliverable shall be deliverable hereunder. Notwithstandingthe foregoing, the requirement to furnish or cause to be furnished an opinion or negative assurance representation under this Section4(l) shall be waived for any Representation Date occurring at a time at which no instruction to the Manager to sell ADSs pursuant to thisAgreement has been delivered by the Company or is pending. Notwithstanding the foregoing, if the Company subsequently decides to sellADSs following any Representation Date when the Company relied on such waiver and did not provide the Manager such opinions or negativeassurance representation pursuant to this Section 4(l), then before the Company instructs the Manager to sell ADSs pursuant to this Agreement,the Company shall provide the Manager with such opinions or negative assurance representation to the extent required under this Section4(l) and not previously delivered.

(m) AuditorBring Down “Comfort” Letter. Within five (5) Trading Days of each Representation Date, unless waived by the Manager, theCompany shall cause (1)the Company’s auditors (the “Accountants”), or other independent accountants satisfactoryto the Manager forthwith to furnish the Manager a letter, and (2)the Chief Financial Officer of the Company forthwith to furnishthe Manager a certificate, in each case dated and delivered within five (5) Trading Days of such Representation Date, in form satisfactoryto the Manager, of the same tenor as the letters and certificate referred to in Section 6 of this Agreement but modified to relate tothe Registration Statement and the Prospectus, as amended and supplemented to the date of such letters and certificate. The requirementto furnish or cause to be furnished a “comfort” letter under this Section 4(m) shall be waived for any Representation Dateother than a Representation Date on which a new Registration Statement is filed and declared effective or a material amendment to theRegistration Statement or Prospectus is made or the Company files its Annual Report on Form 20-F or a material amendment thereto underthe Exchange Act, unless the Manager reasonably requests the deliverables required by this Section 4(m) in connection with a RepresentationDate, upon which request such deliverable shall be deliverable hereunder. Notwithstanding the foregoing, the requirement to deliver orcause to be delivered one or more letters or certificates under this Section 4(m) shall, at the request of the Company, be waived forany Representation Date occurring at a time at which no instruction to the Manager to sell ADSs pursuant to this Agreement has been deliveredby the Company or is pending. Notwithstanding the foregoing, if the Company subsequently decides to sell ADSs following any RepresentationDate when the Company relied on such waiver and did not provide the Manager with a letter or certificate pursuant to this Section 4(m),then before the Company instructs the Manager to sell ADSs pursuant to this Agreement, the Company shall provide the Manager such letteror certificate to the extent required under this Section 4(m) and not previously delivered.

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(n) DueDiligence Session. Upon commencement of the offering of the ADSs under this Agreement (and upon the recommencement of the offeringof the ADSs under this Agreement following the termination of a suspension of sales hereunder lasting more than thirty (30) Trading Days),and within five (5) Trading Days at each Representation Date, the Company will conduct a due diligence session, in form and substance,reasonably satisfactory to the Manager, which shall include representatives of management and Accountants. The Company shall cooperatetimely with any reasonable due diligence request from or review conducted by the Manager or its agents from time to time in connectionwith the transactions contemplated by this Agreement, including, without limitation, providing information and available documents andaccess to appropriate corporate officers and the Company’s agents during regular business hours, and timely furnishing or causingto be furnished such certificates, letters and opinions from the Company, its officers and its agents, as the Manager may reasonably request.The Company shall reimburse the Manager for Manager’s counsel’s fees in each such due diligence update session, up to a maximumof $2,500 per update in connection with Section 4(k)(iv) and $5,000 per update in connection with Section 4(k)(iii), plus any incidentalexpense incurred by the Manager in connection therewith.

(o) Acknowledgmentof Trading. The Company consents to the Manager trading in the Ordinary Shares and ADSs, subject to applicable law, for the Manager’sown account and for the account of its clients at the same time as sales of the ADSs occur pursuant to this Agreement or pursuant to aTerms Agreement.

(p) Disclosureof ADSs Sold. The Company will disclose in its Annual Reports on Form20-F and on Form 6-K when disclosing interim financialreports, as applicable, the number of ADSs sold through the Manager under this Agreement, the Net Proceeds to the Company and the compensationpaid by the Company with respect to sales of ADSs pursuant to this Agreement during the relevant quarter; and, if required by any subsequentchange in Commission policy or request, more frequently by means of a Report of Foreign Private Issuer on Form 6-K or a further ProspectusSupplement.

(q) RescissionRight. If to the knowledge of the Company, the conditions set forth in Section 6 shall not have been satisfied as of the applicableSettlement Date, the Company will offer to any Person who has agreed to purchase ADSs from the Company as the result of an offer to purchasesolicited by the Manager the right to refuse to purchase and pay for such ADSs.

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(r) BringDown of Representations and Warranties. Each acceptance by the Company of an offer to purchase the ADSs hereunder, and each executionand delivery by the Company of a Terms Agreement, shall be deemed to be an affirmation to the Manager that the representations and warrantiesof the Company contained in or made pursuant to this Agreement are true and correct as of the date of such acceptance or of such TermsAgreement as though made at and as of such date, and an undertaking that such representations and warranties will be true and correctas of the Settlement Date for the ADSs relating to such acceptance or as of the Time of Delivery relating to such sale, as the case maybe, as though made at and as of such date (except that such representations and warranties shall be deemed to relate to the RegistrationStatement and the Prospectus as amended and supplemented relating to such ADSs).

(s) Reservationof Ordinary Shares. The Company shall ensure that there are at all times sufficient authorized share capital for issuance of OrdinaryShares to provide for the issuance, free of any preemptive rights, out of its authorized but unissued Ordinary Shares or its OrdinaryShares held in treasury, of a sufficient number of Ordinary Shares authorized for issuance by the Board to be represented by ADSs to bedelivered pursuant to the terms of this Agreement. The Company will use its commercially reasonable efforts to cause the Ordinary Sharesrepresented by ADSs issuable pursuant to this Agreement to be listed for trading on the Trading Market and to maintain such listing.

(t) ObligationUnder Exchange Act. During any period when the delivery of a prospectus relating to the Ordinary Shares represented by the ADSs isrequired (including in circ*mstances where such requirement may be satisfied pursuant to Rule172, 173 or any similar rule) to bedelivered under the Act, the Company will file all documents required to be filed with the Commission pursuant to the Exchange Act withinthe time periods required by the Exchange Act and the regulations thereunder.

(u) DTCFacility. The Company shall cooperate with the Manager and use its reasonable efforts to permit the ADSs to be eligible for clearanceand settlement through the facilities of DTC.

(v) Useof Proceeds. The Company will apply the Net Proceeds from the sale of the ADSs in the manner set forth in the Prospectus.

(w) Filingof Prospectus Supplement. If any sales are made pursuant to this Agreement which are not made in “at the market” offeringsas defined in Rule 415, including, without limitation, any Placement pursuant to a Terms Agreement, the Company shall file a ProspectusSupplement describing the terms of such transaction, the amount of ADSs sold, the price thereof, the Manager’s compensation, andsuch other information as may be required pursuant to Rule 424 and Rule 430B, as applicable, within the time required by Rule 424.

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(x) AdditionalRegistration Statement. To the extent that the Registration Statement is not available for the sales of the Ordinary Shares representedby ADSs as contemplated by this Agreement, the Company shall file a new registration statement with respect to any additional OrdinaryShares and/or ADSs necessary to complete such sales of the Ordinary Shares represented by ADSs and, upon the filing of such registrationstatement, shall cause such registration statement to become effective as promptly as practicable. After the effectiveness of any suchregistration statement, all references to “Registration Statement” included in this Agreement shall be deemed to includesuch new registration statement, including all documents incorporated by reference therein pursuant to Item12 of Form F-3, and allreferences to “Base Prospectus” included in this Agreement shall be deemed to include the final form of prospectus,including all documents incorporated therein by reference, included in any such registration statement at the time such registration statementbecame effective.

(y) EmergingGrowth Company; Foreign Private Issuer. The Company will promptly notify the Manager if the Company ceases to be an Emerging GrowthCompany or a Foreign Private Issuer at any time prior to the later of (i) the sale of all ADSs provided for in the Prospectus and (ii)the termination of this Agreement in accordance with Section 8 herein.

5. Paymentof Expenses. The Company agrees to pay the costs and expenses incident to the performance of its obligations under this Agreement,whether or not the transactions contemplated hereby are consummated, including without limitation: (i)the preparation, printingor reproduction and filing with the Commission of the Registration Statement (including financial statements and exhibits thereto), theProspectus and each Issuer Free Writing Prospectus, and each amendment or supplement to any of them; (ii)the printing (or reproduction)and delivery (including postage, air freight charges and charges for counting and packaging) of such copies of the Registration Statement,the Prospectus, and each Issuer Free Writing Prospectus, and all amendments or supplements to any of them, as may, in each case, be reasonablyrequested for use in connection with the offering and sale of the ADSs; (iii)the preparation, printing, authentication, issuanceand delivery of certificates for the ADSs, including any stamp or transfer taxes in connection with the original issuance and sale ofthe ADSs; (iv)the printing (or reproduction) and delivery of this Agreement, any blue sky memorandum and all other agreements ordocuments printed (or reproduced) and delivered in connection with the offering of the ADSs; (v)the registration of the OrdinaryShares and ADSs under the Exchange Act, if applicable, and the listing of the ADSs on the Trading Market; (vi)any registration orqualification of the Ordinary Shares and Ordinary Shares represented by ADSs for offer and sale under the securities or blue sky lawsof the several states (including filing fees and the reasonable fees and expenses of counsel for the Manager relating to such registrationand qualification); (vii)the transportation and other expenses incurred by or on behalf of Company representatives in connectionwith presentations to prospective purchasers of the ADSs; (viii)the fees and expenses of the Company’s accountants and thefees and expenses of counsel (including local and special counsel) for the Company; (ix) the filing fee under FINRA Rule 5110; (x) thereasonable fees and expenses of the Manager’s counsel, not to exceed $50,000 (excluding any periodic due diligence fees providedfor under Section 4(n)), which shall be paid upon the Execution Time; (xi) fees charged to the Manager by the Depositary in connectionwith the issuance and sale of the ADSs and/or Ordinary Shares, which shall be paid promptly upon request by the Manager; and (xii) allother costs and expenses incident to the performance by the Company of its obligations hereunder.

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6. Conditionsto the Obligations of the Manager. The obligations of the Manager under this Agreement, any Terms Agreement and any Sales Notice shallbe subject to (i)the accuracy of the representations and warranties on the part of the Company contained herein as of the ExecutionTime, each Representation Date, and as of each Applicable Time, Settlement Date and Time of Delivery, (ii)the performance by theCompany of its obligations hereunder and (iii)the following additional conditions:

(a) Filingof Prospectus Supplement. The Prospectus, and any supplement thereto, required by Rule424 to be filed with the Commission havebeen filed in the manner and within the time period required by Rule424(b) with respect to any sale of Ordinary Shares representedby ADSs; each Prospectus Supplement shall have been filed in the manner required by Rule424(b) within the time period required hereunderand under the Act; any other material required to be filed by the Company pursuant to Rule433(d) under the Act, shall have beenfiled with the Commission within the applicable time periods prescribed for such filings by Rule433; and no stop order suspendingthe effectiveness of the Registration Statement or any notice objecting to its use shall have been issued and, to the knowledge of theCompany, no proceedings for that purpose shall have been instituted or threatened.

(b) Deliveryof Opinions. The Company shall have caused the (i) Company U.S. Counsel to furnish to the Manager its opinion and negative assurancestatement, (ii) Company Israeli Counsel to furnish to the Manager its opinion, and (iii) Depositary Counsel to furnish to the Managerits opinion, in each case, dated as of such date and addressed to the Manager in form and substance acceptable to the Manager.

(c) Deliveryof Officer’s Certificate. The Company shall have furnished or caused to be furnished to the Manager a certificate of the Companysigned by the Chief Executive Officer or the President and the principal financial or accounting officer of the Company, dated as of suchdate, to the effect that the signers of such certificate have carefully examined the Registration Statement, the Prospectus, any ProspectusSupplement and any documents incorporated by reference therein and any supplements or amendments thereto and this Agreement and that:

(i) therepresentations and warranties of the Company in this Agreement are true and correct in all material respects on and as of such date withthe same effect as if made on such date and the Company has complied in all material respects with all the agreements and satisfied allthe conditions on its part to be performed or satisfied at or prior to such date;

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(ii) nostop order suspending the effectiveness of the Registration Statement or any notice objecting to its use has been issued and, to the Company’sknowledge, no proceedings for that purpose have been instituted or threatened; and

(iii) sincethe date of the most recent financial statements included in the Registration Statement, the Prospectus and the Incorporated Documents,there has been no Material Adverse Effect on the condition (financial or otherwise), results of operations, earnings, business or propertiesof the Company and its subsidiaries, taken as a whole, whether or not arising from transactions in the ordinary course of business, exceptas set forth in or contemplated in the Registration Statement and the Prospectus.

(d) Deliveryof Accountants’ “Comfort” Letter. The Company shall have requested and caused the Accountants to have furnishedto the Manager letters (which may refer to letters previously delivered to the Manager), dated as of such date, in form and substancesatisfactory to the Manager, confirming that they are independent accountants within the meaning of the Act and the Exchange Act and therespective applicable rules and regulations adopted by the Commission thereunder and that they have performed a review of any unauditedinterim financial information of the Company included or incorporated by reference in the Registration Statement and the Prospectus andprovide customary “comfort” as to such review in form and substance satisfactory to the Manager.

(e) NoMaterial Adverse Event. Since the respective dates as of which information is disclosed in the Registration Statement, the Prospectusand the Incorporated Documents, except as otherwise stated therein, there shall not have been (i)any change or decrease in previouslyreported results specified in the letter or letters referred to in paragraph(d) of this Section 6 or (ii)any change, or anydevelopment involving a prospective change, in or affecting the condition (financial or otherwise), earnings, business or properties ofthe Company and its subsidiaries taken as a whole, whether or not arising from transactions in the ordinary course of business, exceptas set forth in or contemplated in the Registration Statement, the Prospectus and the Incorporated Documents (exclusive of any amendmentor supplement thereto) the effect of which, in any case referred to in clause(i) or (ii)above, is, in the sole judgment ofthe Manager, so material and adverse as to make it impractical or inadvisable to proceed with the offering or delivery of the ADSs ascontemplated by the Registration Statement (exclusive of any amendment thereof), the Incorporated Documents and the Prospectus (exclusiveof any amendment or supplement thereto).

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(f) Paymentof All Fees. The Company shall have paid the required Commission filing fees relating to the Ordinary Shares and ADSs within the timeperiod required by Rule456(b)(1)(i) of the Act without regard to the proviso therein and otherwise in accordance with Rules456(b)and 457(r) of the Act and, if applicable, shall have updated the “Calculation of Registration Fee” table in accordance withRule456(b)(1)(ii) either in a post-effective amendment to the Registration Statement or on the cover pageof a prospectus filedpursuant to Rule424(b).

(g) NoFINRA Objections. FINRA shall not have raised any objection with respect to the fairness and reasonableness of the terms and arrangementsunder this Agreement.

(h) ADSsListed on Trading Market. The ADSs shall have been listed and admitted and authorized for trading on the Trading Market, and satisfactoryevidence of such actions shall have been provided to the Manager.

(i) DepositAgreement. The Deposit Agreement shall be in full force and effect, and the Company shall have taken all action necessary to permitthe deposit of the Ordinary Shares with the Depositary and the issuance of the ADSs in accordance with the Deposit Agreement.

(j) OtherAssurances. Prior to each Settlement Date and Time of Delivery, as applicable, the Company shall have furnished to the Manager suchfurther information, certificates and documents as the Manager may reasonably request.

If any of the conditions specifiedin this Section 6 shall not have been fulfilled when and as provided in this Agreement, or if any of the opinions and certificates mentionedabove or elsewhere in this Agreement shall not be reasonably satisfactory in form and substance to the Manager and counsel for the Manager,this Agreement and all obligations of the Manager hereunder may be canceled at, or at any time prior to, any Settlement Date or Time ofDelivery, as applicable, by the Manager. Notice of such cancellation shall be given to the Company in writing or by telephone and confirmedin writing by email.

The documents required tobe delivered by this Section 6 shall be delivered to the office of Ellenoff Grossman & Schole LLP, counsel for the Manager, at 1345Avenue of the Americas, New York, New York 10105, email: capmkts@egsllp.com, on each such date as provided in this Agreement.

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7. Indemnificationand Contribution.

(a) Indemnificationby Company. The Company agrees to indemnify and hold harmless the Manager, the directors, officers, employees and agents of the Managerand each person who controls the Manager within the meaning of either the Act or the Exchange Act against any and all losses, claims,damages or liabilities, joint or several, to which they or any of them may become subject under the Act, the Exchange Act or other Federalor state statutory law or regulation, at common law or otherwise, insofar as such losses, claims, damages or liabilities (or actions inrespect thereof) arise out of or are based upon any untrue statement or alleged untrue statement of a material fact contained in the RegistrationStatement for the registration of the Ordinary Shares and ADSs as originally filed or in any amendment thereof, or in the Base Prospectus,any Prospectus Supplement, the Prospectus, any Issuer Free Writing Prospectus, or in any amendment thereof or supplement thereto, or ariseout of or are based upon the omission or alleged omission to state therein a material fact required to be stated therein or necessaryto make the statements therein not misleading or arise out of or are based upon any Proceeding, commenced or threatened (whether or notthe Manager is a target of or party to such Proceeding) or result from or relate to any breach of any of the representations, warranties,covenants or agreements made by the Company in this Agreement, and agrees to reimburse each such indemnified party for any legal or otherexpenses reasonably incurred by them in connection with investigating or defending any such loss, claim, damage, liability or action;provided, however, that the Company will not be liable in any such case to the extent that any such loss, claim, damageor liability arises out of or is based upon any such untrue statement or alleged untrue statement or omission or alleged omission madetherein in reliance upon and in conformity with written information furnished to the Company by the Manager specifically for inclusiontherein. This indemnity agreement will be in addition to any liability that the Company may otherwise have.

(b) Indemnificationby Manager. The Manager agrees to indemnify and hold harmless the Company, each of its directors, each of its officers who signs theRegistration Statement, and each person who controls the Company within the meaning of either the Act or the Exchange Act, to the sameextent as the foregoing indemnity from the Company to the Manager, but only with reference to written information relating to the Managerfurnished to the Company by the Manager specifically for inclusion in the documents referred to in the foregoing indemnity; provided,however, that in no case shall the Manager be responsible for any amount in excess of the Broker Fee applicable to the ADSs andpaid hereunder. This indemnity agreement will be in addition to any liability which the Manager may otherwise have.

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(c) IndemnificationProcedures. Promptly after receipt by an indemnified party under this Section7 of notice of the commencement of any action,such indemnified party will, if a claim in respect thereof is to be made against the indemnifying party under this Section7, notifythe indemnifying party in writing of the commencement thereof; but the failure so to notify the indemnifying party (i)will not relieveit from liability under paragraph(a) or(b) above unless and to the extent it did not otherwise learn of such action and suchfailure results in the forfeiture by the indemnifying party of substantial rights and defenses and (ii)will not, in any event, relievethe indemnifying party from any obligations to any indemnified party other than the indemnification obligation provided in paragraph(a)or (b)above. The indemnifying party shall be entitled to appoint counsel of the indemnifying party’s choice at the indemnifyingparty’s expense to represent the indemnified party in any action for which indemnification is sought (in which case the indemnifyingparty shall not thereafter be responsible for the fees and expenses of any separate counsel retained by the indemnified party or partiesexcept as set forth below); provided, however, that such counsel shall be reasonably satisfactory to the indemnified party.Notwithstanding the indemnifying party’s election to appoint counsel to represent the indemnified party in an action, the indemnifiedparty shall have the right to employ separate counsel (including local counsel), and the indemnifying party shall bear the documentedand reasonable fees, costs and expenses of such separate counsel if (i)the use of counsel chosen by the indemnifying party to representthe indemnified party would present such counsel with a conflict of interest, (ii)the actual or potential defendants in, or targetsof, any such action include both the indemnified party and the indemnifying party and the indemnified party shall have reasonably concludedthat there may be legal defenses available to it and/or other indemnified parties which are different from or additional to those availableto the indemnifying party, (iii)the indemnifying party shall not have employed counsel reasonably satisfactory to the indemnifiedparty to represent the indemnified party within a reasonable time after notice of the institution of such action or (iv)the indemnifyingparty shall authorize the indemnified party to employ separate counsel at the expense of the indemnifying party. An indemnifying partywill not, without the prior written consent of the indemnified parties, settle or compromise or consent to the entry of any judgment withrespect to any pending or threatened claim, action, suit or proceeding in respect of which indemnification or contribution may be soughthereunder (whether or not the indemnified parties are actual or potential parties to such claim or action) unless such settlement, compromiseor consent includes an unconditional release of each indemnified party from all liability arising out of such claim, action, suit or proceeding.

(d) Contribution.In the event that the indemnity provided in paragraph(a), (b)or (c)of this Section7 is unavailable to or insufficientto hold harmless an indemnified party for any reason, the Company and the Manager agree to contribute to the aggregate losses, claims,damages and liabilities (including legal or other expenses reasonably incurred in connection with investigating or defending the same)(collectively “Losses”) to which the Company and the Manager may be subject in such proportion as is appropriate toreflect the relative benefits received by the Company on the one hand and by the Manager on the other from the offering of the ADSs; provided,however, that in no case shall the Manager be responsible for any amount in excess of the Broker Fee applicable to the ADSs andpaid hereunder. If the allocation provided by the immediately preceding sentence is unavailable for any reason, the Company and the Managerseverally shall contribute in such proportion as is appropriate to reflect not only such relative benefits but also the relative faultof the Company on the one hand and of the Manager on the other in connection with the statements or omissions which resulted in such Lossesas well as any other relevant equitable considerations. Benefits received by the Company shall be deemed to be equal to the total netproceeds from the offering (before deducting expenses) received by it, and benefits received by the Manager shall be deemed to be equalto the Broker Fee applicable to the ADSs and paid hereunder as determined by this Agreement. Relative fault shall be determined by referenceto, among other things, whether any untrue or any alleged untrue statement of a material fact or the omission or alleged omission to statea material fact relates to information provided by the Company on the one hand or the Manager on the other, the intent of the partiesand their relative knowledge, access to information and opportunity to correct or prevent such untrue statement or omission. The Companyand the Manager agree that it would not be just and equitable if contribution were determined by pro rata allocation or any other methodof allocation which does not take account of the equitable considerations referred to above. Notwithstanding the provisions of this paragraph(d),no person guilty of fraudulent misrepresentation (within the meaning of Section11(f) of the Act) shall be entitled to contributionfrom any person who was not guilty of such fraudulent misrepresentation. For purposes of this Section7, each person who controlsthe Manager within the meaning of either the Act or the Exchange Act and each director, officer, employee and agent of the Manager shallhave the same rights to contribution as the Manager, and each person who controls the Company within the meaning of either the Act orthe Exchange Act, each officer of the Company who shall have signed the Registration Statement and each director of the Company shallhave the same rights to contribution as the Company, subject in each case to the applicable terms and conditions of this paragraph(d).

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8. Termination.

(a) TheCompany shall have the right, by giving written notice as hereinafter specified, to terminate this Agreement in its sole discretion atany time upon five (5) Business Days’ prior written notice. Any such termination shall be without liability of any party to anyother party except that (i)with respect to any pending sale, through the Manager for the Company, the obligations of the Company,including in respect of compensation of the Manager, shall remain in full force and effect notwithstanding the termination and (ii)theprovisions of Sections5, 6, 7, 8, 9, 10, 12, the second sentence of 13, 14 and 15 of this Agreement shall remain in full force andeffect notwithstanding such termination.

(b) TheManager shall have the right, by giving written notice as hereinafter specified, to terminate the provisions of this Agreement relatingto the solicitation of offers to purchase the ADSs in its sole discretion at any time. Any such termination shall be without liabilityof any party to any other party except that the provisions of Sections5, 6, 7, 8, 9, 10, 12, the second sentence of 13, 14 and 15of this Agreement shall remain in full force and effect notwithstanding such termination.

(c) ThisAgreement shall remain in full force and effect until such date that this Agreement is terminated pursuant to Sections8(a) or (b)aboveor otherwise by mutual agreement of the parties, provided that any such termination by mutual agreement shall in all cases be deemed toprovide that Sections5, 6, 7, 8, 9, 10, 12, the second sentence of 13, 14 and 15 of this Agreement shall remain in full force andeffect.

(d) Anytermination of this Agreement shall be effective on the date specified in such notice of termination, provided that such termination shallnot be effective until the close of business on the date of receipt of such notice by the Manager or the Company, as the case may be.If such termination shall occur prior to the Settlement Date or Time of Delivery for any sale of the ADSs, such sale of the ADSs shallsettle in accordance with the provisions of Section 2(b) of this Agreement.

(e) Inthe case of any purchase of ADSs by the Manager pursuant to a Terms Agreement, the obligations of the Manager pursuant to such Terms Agreementshall be subject to termination, in the absolute discretion of the Manager, by prompt oral notice given to the Company prior to the Timeof Delivery relating to such ADSs, if any, and confirmed promptly by electronic mail, if since the time of execution of the Terms Agreementand prior to such delivery and payment, (i)trading in the ADSs shall have been suspended by the Commission or the Trading Marketor trading in securities generally on the Trading Market shall have been suspended or limited or minimum prices shall have been establishedon such exchange, (ii)a banking moratorium shall have been declared either by Federal or New York State authorities or (iii)thereshall have occurred any outbreak or escalation of hostilities, declaration by the United States of a national emergency or war, or othercalamity or crisis the effect of which on financial markets is such as to make it, in the sole judgment of the Manager, impractical orinadvisable to proceed with the offering or delivery of the ADSs as contemplated by the Prospectus (exclusive of any amendment or supplementthereto).

9. Representationsand Indemnities to Survive. The respective agreements, representations, warranties, indemnities and other statements of the Companyor its officers and of the Manager set forth in or made pursuant to this Agreement will remain in full force and effect, regardless ofany investigation made by the Manager or the Company or any of the officers, directors, employees, agents or controlling persons referredto in Section7, and will survive delivery of and payment for the ADSs.

10. Notices.All communications hereunder will be in writing and effective only on receipt, and will be mailed, delivered, or e-mailed to the addressesof the Company and the Manager, respectively, set forth on the signature page hereto.

11. Successors.This Agreement will inure to the benefit of and be binding upon the parties hereto and their respective successors and the officers, directors,employees, agents and controlling persons referred to in Section7, and no other person will have any right or obligation hereunder.

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12. NoFiduciary Duty. The Company hereby acknowledges that (a)the purchase and sale of the ADSs pursuant to this Agreement is an arm’s-lengthcommercial transaction between the Company, on the one hand, and the Manager and any affiliate through which it may be acting, on theother, (b)the Manager is acting solely as sales agent and/or principal in connection with the purchase and sale of the Company’ssecurities and not as a fiduciary of the Company and (c)the Company’s engagement of the Manager in connection with the offeringand the process leading up to the offering is as independent contractors and not in any other capacity. Furthermore, the Company agreesthat it is solely responsible for making its own judgments in connection with the offering (irrespective of whether the Manager has advisedor is currently advising the Company on related or other matters). The Company agrees that it will not claim that the Manager has renderedadvisory services of any nature or respect, or owe an agency, fiduciary or similar duty to the Company, in connection with such transactionor the process leading thereto.

13. Integration.This Agreement and any Terms Agreement supersede all prior agreements and understandings (whether written or oral) between the Companyand the Manager with respect to the subject matter hereof. Notwithstanding anything herein to the contrary, the letter agreement, datedJuly 2, 2024, by and between the Company and the Manager shall continue to be effective and the terms therein shall continue to surviveand be enforceable by the Manager in accordance with its terms, provided that, in the event of a conflict between the terms of the letteragreement and this Agreement, the terms of this Agreement shall prevail.

14. Amendments;Waivers. No provision of this Agreement may be waived, modified, supplemented or amended except in a written instrument signed, inthe case of an amendment, by the Company and the Manager. No waiver of any default with respect to any provision, condition or requirementof this Agreement shall be deemed to be a continuing waiver in the future or a waiver of any subsequent default or a waiver of any otherprovision, condition or requirement hereof, nor shall any delay or omission of any party to exercise any right hereunder in any mannerimpair the exercise of any such right.

15. ApplicableLaw. This Agreement and any Terms Agreement will be governed by and construed in accordance with the laws of the State of New Yorkapplicable to contracts made and to be performed within the State of NewYork. Each of the Company and the Manager: (i) agrees thatany legal suit, action or proceeding arising out of or relating to this Agreement shall be instituted exclusively in New York SupremeCourt, County of New York, or in the United States District Court for the Southern District of New York, (ii) waives any objection whichit may have or hereafter to the venue of any such suit, action or proceeding, and (iii) irrevocably consents to the exclusive jurisdictionof the New York Supreme Court, County of New York, and the United States District Court for the Southern District of New York in any suchsuit, action or proceeding. Each of the Company and the Manager further agrees to accept and acknowledge service of any and all processwhich may be served in any such suit, action or proceeding in the New York Supreme Court, County of New York, or in the United StatesDistrict Court for the Southern District of New York and agrees that service of process upon the Company mailed by certified mail to theCompany’s address shall be deemed in every respect effective service of process upon the Company, in any such suit, action or proceeding,and service of process upon the Manager mailed by certified mail to the Manager’s address shall be deemed in every respect effectiveservice process upon the Manager, in any such suit, action or proceeding. If either party shall commence an action or proceeding to enforceany provision of this Agreement, then the prevailing party in such action or proceeding shall be reimbursed by the other party for itsreasonable attorney’s fees and other costs and expenses incurred with the investigation, preparation and prosecution of such actionor proceeding.

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16. Submissionto Jurisdiction. The Company hereby submits to the exclusive jurisdiction of the U.S. federal and New York state courts in the Boroughof Manhattan in The City of New York in any suit or proceeding arising out of or relating to this Agreement or the transactions contemplatedhereby. The Company waives any objection which it may now or hereafter have to the laying of venue of any such suit or proceeding in suchcourts. The Company agrees that final judgment in any such suit, action or proceeding brought in such court shall be conclusive and bindingupon the Company and may be enforced in any court to the jurisdiction of which Company is subject by a suit upon such judgment.

17. JudgmentCurrency. The Company agrees to indemnify the Manager, its directors, officers, affiliates and each person, if any, who controls theManager within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act, against any loss incurred by the Manageras a result of any judgment or order being given or made for any amount due hereunder and such judgment or order being expressed and paidin a currency (the "Judgment Currency") other than U.S. dollars and as a result of any variation as between (i) the rateof exchange at which the U.S. dollar amount is converted into the Judgment Currency for the purpose of such judgment or order, and (ii)the rate of exchange at which such indemnified person is able to purchase U.S. dollars with the amount of the Judgment Currency actuallyreceived by the indemnified person. The foregoing indemnity shall constitute a separate and independent obligation of the Company andshall continue in full force and effect notwithstanding any such judgment or order as aforesaid. The term "rate of exchange"shall include any premiums and costs of exchange payable in connection with the purchase of, or conversion into, the relevant currency.

18. Waiverof Immunity. To the extent that the Company has or hereafter may acquire any immunity (sovereign or otherwise) from jurisdiction ofany court of (i) the State of Israel, or any political subdivision thereof, (ii) the United States or the State of New York, (iii) anyjurisdiction in which it owns or leases property or assets or from any legal process (whether through service of notice, attachment priorto judgment, attachment in aid of execution, execution, set-off or otherwise) with respect to themselves or their respective propertyand assets or this Agreement, the Company hereby irrevocably waives such immunity in respect of its obligations under this Agreement tothe fullest extent permitted by applicable law.

19. Waiverof Jury Trial. The Company hereby irrevocably waives, to the fullest extent permitted by applicable law, any and all right to trialby jury in any legal proceeding arising out of or relating to this Agreement, any Terms Agreement or the transactions contemplated herebyor thereby.

20. Counterparts.This Agreement and any Terms Agreement may be executed in one or more counterparts, each one of which shall be an original, with the sameeffect as if the signatures thereto and hereto were upon one and the same agreement. Counterparts may be delivered via electronic mail(including any electronic signature covered by the U.S. federal ESIGN Act of 2000, Uniform Electronic Transactions Act, the ElectronicSignatures and Records Act or other applicable law, e.g., www.docusign.com) or other transmission method and any counterpart so deliveredshall be deemed to have been duly and validly delivered and be valid and effective for all purposes.

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21. Headings.The section headings used in this Agreement and any Terms Agreement are for convenience only and shall not affect the construction hereof.

If the foregoing is in accordancewith your understanding of our agreement, please sign and return to us the enclosed duplicate hereof, whereupon this letter and your acceptanceshall represent a binding agreement among the Company and the Manager.

Very truly yours,

Address for Notice:

26 Ben Gurion Street

Ramat Gan 5257346 Israel

Attention: Motti Farbstein

E-mail: motti@canfite.co.il

The foregoing Agreement is hereby confirmed and acceptedas of the date first written above.

H.C. WAINWRIGHT & CO., LLC

Address for Notice:

430 Park Avenue
New York, New York 10022
Attention: Chief Executive Officer

E-mail: notices@hcwco.com

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Form of Terms Agreement

ANNEX I

CAN-FITEBIOPHARMA lTD.

TERMS AGREEMENT

Dear Sirs:

Can-FiteBioPharma Ltd. (the “Company”) proposes, subject to the terms and conditions stated herein and in the At The MarketOffering Agreement, dated August 30, 2024 (the “At The Market Offering Agreement”), between the Company and H.C. Wainwright& Co., LLC (“Manager”), to issue and sell to Manager the securities specified in the ScheduleI hereto(the “Purchased ADSs”).

Eachof the provisions of the At The Market Offering Agreement not specifically related to the solicitation by the Manager, as agent of theCompany, of offers to purchase securities is incorporated herein by reference in its entirety, and shall be deemed to be part of thisTerms Agreement to the same extent as if such provisions had been set forth in full herein. Each of the representations and warrantiesset forth therein shall be deemed to have been made at and as of the date of this Terms Agreement and the Time of Delivery, except thateach representation and warranty in Section3 of the At The Market Offering Agreement which makes reference to the Prospectus (astherein defined) shall be deemed to be a representation and warranty as of the date of the At The Market Offering Agreement in relationto the Prospectus, and also a representation and warranty as of the date of this Terms Agreement and the Time of Delivery in relationto the Prospectus as amended and supplemented to relate to the Purchased ADSs.

Anamendment to the Registration Statement (as defined in the At The Market Offering Agreement), or a supplement to the Prospectus, as thecase may be, relating to the Purchased ADSs, in the form heretofore delivered to the Manager is now proposed to be filed with the Securitiesand Exchange Commission.

Subjectto the terms and conditions set forth herein and in the At The Market Offering Agreement which are incorporated herein by reference, theCompany agrees to issue and sell to the Manager and the latter agrees to purchase from the Company the number of Purchased ADSs at thetime and place and at the purchase price set forth in the ScheduleI hereto.

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If the foregoing isin accordance with your understanding, please sign and return to us a counterpart hereof, whereupon this Terms Agreement, including thoseprovisions of the At The Market Offering Agreement incorporated herein by reference, shall constitute a binding agreement between theManager and the Company.

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